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Karin Schillén, Professor

Research interests

Self-assembly and phase behavior of amphiphilic block copolymers and their applications, interactions of stimuli-responsive block copolymers/polyelectrolytes/biopolymers with bile salts and surfactants. Formation of supramolecular structures of bile salt derivatives. Main methods of investigation: dynamic and static light scattering, small angle X-ray scattering, differential scanning and titration calorimetry, cryogenic transmission electron microscopy.

Research projects

  • Oppositely charged polymer-bile salt systems: To provide fundamental understanding of supramolecular structures of mixed complexes of bile salt biosurfactants and oppositely charged biocompatible polymers and their intermolecular interactions
  • The interaction between stimuli-responsive block copolymers and bile salts
  • Self-organized supramolecular structures of oppositely charged block copolymers and bile salts
  • Supramolecular structures of bile salt derivates in aqueous solutions
  • Soluble complex salts of surfactant ions and polymeric counterions: Composite macromolecular self-assembly
  • PEO-PPO-PEO (Pluronic®/Synperonic®) block copolymer systems. Physico-chemical studies of the self-assembly of PEO-PPO-PEO triblock copolymers and their interaction and co-assembly with nonionic and ionic surfactants, bile salts and polyelectrolytes in aqueous solution

Academic background

  • 2008 Professor of Physical Chemistry – Surface and Colloid Chemistry, Lund University
  • 2002 Docent in Physical Chemistry, Lund University
  • 1996–1997 Postdoctoral Fellow (Swedish Research Council, VR), University of Toronto, Dept. of Chemistry, Canada. Project: "Fluorescence spectroscopy on fluorescently labelled block copolymers"
  • 1994–1996 Postdoctoral Fellow, Royal Institute of Technology (KTH), Sweden. Project: "Surface force measurements on block copolymers"
  • 1994 PhD in Physical Chemistry, Uppsala University, Thesis: "Solution properties of block copolymers studied using light scattering". Supervised by Prof. Wyn Brown
  • 1989 Master of Science (MSc) in Physics and Chemistry, Uppsala University

Faculty positions

  • 2019 Visiting Professor (Guest professorship), Department of Chemistry, La Sapienza University of Rome
  • 2008–present Professor, Division of Physical Chemistry, Lund University
  • 2003–2008 Associate Professor/Senior Lecturer, Division of Physical Chemistry, Lund University
  • 1997–2003 Assistant Professor, Division of Physical Chemistry, Lund University

Research programs and networks

  • 2024–2028 Member of the Excellence Center "Commonalities in membrane molecular interactions (COMMONS)" through the Swedish Research Council
  • 2018–2024 Swedish coordinator of a Joint China-Sweden Mobility Program with Institute of Chemistry, Chinese Academy of Science, Beijing from The Swedish Foundation for International Cooperation Research and Higher Education (STINT)
  • 2006–2016 Member of the Linnaeus Center of Excellence "Organzing Molecular Matter (OMM)" through the Swedish Research Council
  • 2003–2007 Member of the Swedish Foundation for Strategic Research (SSF) program Colloidal Structures from Self-association (COLINTECH)
  • 1998–2005 Member of the Competence Centre for Amphiphilic Polymers from Renewable Resources (CAP) through VINNOVA

Graduate students brought to PhD

Past postdoctoral researchers

  • 2004 Dmitri Pebalk
  • 2009–2010 Guiseppe Lazzara

Past undergraduate students and visiting PhD students/postdocs

  • 2024 Mateus Peres Bomediano (visiting PhD student, Campinas University (UNICAMP), Brazil) 
  • 2024 Alvaro Javier Patiño Agudelo (visiting postdoc, Campinas University (UNICAMP), Brazil) 
  • 2023 Karolina Krautforst (visiting PhD student, University of Cagliari, Italy) 
  • 2023 Valeria D'Annibale (visiting PhD student, La Sapienza Rome University, Italy) 
  • 2023 Leonardo Ariodante (visiting PhD student, La Sapienza Rome University, Italy) 
  • 2022 Claudia Marconi (visiting PhD student, La Sapienza Rome University, Italy)
  • 2020 Suelen Gauna Trindade (visiting PhD student, University of Campinas (UNICAMP), Brazil)
  • 2018-2020 Marco Fornasier (visiting PhD student, University of Cagliari, Italy)
  • 2016 Jacopo Cautela (visiting PhD student, La Sapienza Rome University, Italy)
  • 2014 Veronica Lattanzi (Eramus internship, La Sapienza Rome University, Italy)
  • 2014 Marta Gubitosi (visiting PhD student, La Sapienza Rome University, Italy)
  • 2014 Valeria Meli (visiting PhD student, University of Cagliari, Italy)
  • 2014 Caroline Anderberg Haglund, MSc thesis: "Interaction between PEO-PPO-PEO Block Copolymers and a Bile Salt"
  • 2013 Marta Gubitosi (visiting PhD student, La Sapienza Rome University, Italy)
  • 2009 Michael Fuchs, BSc thesis: "How Polydispersity of PEO-PPO-PEO Block Copolymers Affects the Mesoporous Silica Materials"
  • 2007 John Janiak, MSc thesis: "DNA-PAMAM Dendrimer Complex formation Studied using Light Scattering and Steady-State Fluorescence Spectroscopy"
  • 2005 Ikes Montes, MSc thesis: "A Study of PEO-PPO-PEO Triblock Copolymers: L121-F127-Water Phase Behavior, Vesicle Formation and Characterization" (Erasmus student, University of Basque Country, Spain)
  • 2003 Telma Costa (Eramus internship, Coimbra University, Portugal)
  • 2000–2002 Rodrigo Cardoso da Silva (visiting PhD student, Campinas University (UNICAMP), Brazil)
  • 2002 Anna Niemiec (Erasmus internship, Krakow University, Poland)

Teaching

Commissions of trust

  • Member of boards: Board member of Surface and Material Chemistry Section at The Swedish Chemical Society 2015–2021; Board member of The Swedish Foundation for Strategic Research program "Colloid and Interface Technology" (COLINTECH) 1998–2002; Ordinary council member of International Association of Colloid and Interface Scientists (IACIS) 2022–2025
  • Member of the review panel in Analytical, Physical, and Theoretical Chemistry at the Swedish Research Council, VR 2023

Publications

  • 101. D'Annibale, V.; Piccirillo, L.; Pacini, B.; Sennato, S.; Marconi, C.; Del Giudice, A.; di Gregorio, M. C.; Schillén, K.; D'Abramo, M.; D’Annibale, A.; Monti, D.; Galantini, L., A Spectroscopic and Structural Study on the Solvent-Promoted Stereospecific Self-Assembly of New Porphyrin-Bile Salt Conjugates. Colloids Surf., A 2024, 700, 134507. https://doi.org/10.1016/j.colsurfa.2024.134507
  • 100. Gjerde, N. S.; Del Giudice, A.; Zhu, K.; Knudsen, K. D.; Galantini, L.; Schillén, K.; Nyström, B., Synthesis and Characterization of a Thermoresponsive Copolymer with an LCST–UCST-like Behavior and Exhibiting Crystallization. ACS Omega 2023, 8 (34), 31145–31154. https://pubs.acs.org/doi/full/10.1021/acsomega.3c03162
  • 99. Ferreira, G.; Ram-On, M.; Talmon, Y.; Schillén, K.; Piculell, L.; Loh, W., Complexes of Charged-Neutral Block-Copolymers and Surfactants: Process-Dependent Features and Long-Term Stability of Their Aqueous dispersions. Langmuir 2023, 39 (11), 4113-4124. https://pubs.acs.org/doi/10.1021/acs.langmuir.2c03500
  • 98. Tan, J. J.; Gjerde, N.; Del Giudice, A.; Knudsen, K. D.; Galantini, L.; Du, G.; Schillén, K.; Sande, S. A.; Nyström, B., Interactions in Aqueous Mixtures of Cationic Hydroxyethyl Cellulose and Different Anionic Bile Salts. J. Agric. Food Chem. 2023, 71, 3732-3741. https://doi.org/10.1021/acs.jafc.3c00076
  • 97. Zhang, L.; Yaxun Fan, Y.; Galantini, L.; Schillén, K.; Del Giudice, A.; Du, G.; Wang, Y., Noncovalent Bile Acid Oligomers as Facial Amphiphilic Antimicrobials. Langmuir 2023, 39 (1), 495–506.  https://doi.org/10.1021/acs.langmuir.2c02787
  • 96. Santilli, A.; Lapi, A.; Cautela, J.; D’Abramo, M.; Chen, C. G.; Del Giudice, A.; Sennato, S.; Belić, D.; Tellini, V. H. S.; Schillén, K.; di Gregorio, M. C.; Galantini, L., Bioderived, Chiral and Stable 1-Dimensional Light-Responsive Nanostructures: Interconversion between Tubules and Twisted Ribbons. J. Colloid Interface Sci. 2022, 623, 723-734. https://doi.org/10.1016/j.jcis.2022.05.025
  • 95. Du, G.; Belić, D.; Del Giudice, A.; Alfredsson, V.; Carnerup, A. M.; Zhu, K.; Nyström, B.; Wang, Y.; Galantini, L.; Schillén, K., Condensed Supramolecular Helices: The Twisted Sisters of DNA. Angew. Chem. Int. Ed. 2022, 61, e202113279. https://doi.org/10.1002/anie.202113279
  • 94. Fornasier, M.; Pireddu, R.; Del Giudice, A.; Sinico, C.; Nylander, T.; Schillén, K.; Galantini, L.; Murgia, S., Tuning Lipid Structure by Bile Salts: Hexosomes for Topical Administration of Catechin. Colloids Surf., B 2021, 199, 111564. https://doi.org/10.1016/j.colsurfb.2021.111564
  • 93. Cautela, J.; Stenqvist, B.; Schillén, K.; Belić, D.; Månsson, L.; Hagemans, F.; Seuss, M.; Fery, A.; Crassous, J.; Galantini, L., Supracolloidal Atomium. ACS Nano 2020, 14, 15748-15756. https://doi.org/10.1021/acsnano.0c06764
  • 92. Fornasier, M.; Porcheddu, A.; Casu, A.; Raghavan, S. R.; Jönsson, P.; Schillén, K.; Murgia, S., Surface-Modified Nanoerythrosomes for Potential Optical Imaging Diagnostics. J. Colloid Interface Sci. 2021, 582, 246-253. https://doi.org/10.1016/j.jcis.2020.08.032
  • 91. Du, G.; Del Giudice, A.; Alfredsson, V.; Carnerup, A. M.; Pavel, N. V.; Loh, W.; Masci, G.; Nyström, B.; Galantini, L.;  Schillén, K., Effect of Temperature on the Association Behavior in Aqueous Mixtures of an Oppositely Charged Amphiphilic Block Copolymer and Bile Salt. Polymer 2020, 206, 122871. https://doi.org/10.1016/j.polymer.2020.122871
  • 90. Tasca, E.; Andreozzi, P.; Del Giudice, A.; Galantini, L.; Schillén, K.; Giuliani, A. M.; los Angeles Ramirez, M.; Moya, S.; Giustini, M., Poloxamer/Sodium Cholate Co-Formulation for Micellar Encapsulation of Doxorubicin with High Efficiency for Intracellular Delivery: An In-Vitro Bioavailability Study. J. Colloid Interface Sci. 2020, 579, 551-561. https://doi.org/10.1016/j.jcis.2020.06.096
  • 89. Cautela, J.; Severoni, E.; Redondo-Gómez, C.; di Gregorio, M. C.; Del Giudice, A.; Sennato, S.; Angelini, R.; D’Abramo, M.; Schillén, K.; Galantini, L., C-12 vs C-3 Substituted Bile Salts: An Example of the Effects of Substituent Position and Orientation on the Self-Assembly of Steroid Surfactant Isomers. Colloids Surf., B 2020, 185, 110556. https://doi.org/10.1016/j.colsurfb.2019.110556
  • 88. Schillén, K.; Galantini, L.; Du, G.; Del Giudice, A.; Alfredsson, V.; Carnerup, A. M.; Pavel, N. V.; Masci, G.; Nyström, B., Block Copolymers as Sequestrants: Intriguing Structures Formed in a Mixture of an Oppositely Charged Amphiphilic Block Copolymer and Bile Salt. Phys. Chem. Chem. Phys., 2019, 21, 12518-12529. https://doi.org/10.1039/C9CP01744E
  • 87. Tasca, E.; Del Giudice, A.; Galantini, L.; Schillén, K.; Giuliani, A. M.; Giustini, M., A Fluorescence Study of the Loading and Time Stability of Doxorubicin in Sodium Cholate/PEO-PPO-PEO Triblock Copolymer Mixed Micelles. J. Colloid Int. Sci. 2019, 540, 593-601. https://doi.org/10.1016/j.jcis.2020.06.096
  • 86. Travaglini, L.; Giordano, C.; D'Annibale, A.; Gubitosi, M.; di Gregorio, M. C.; Schillén, K.; Stefanucci, A.; Mollica, A.; Pavel, N. V.; Galantini, L., Twisted Nanoribbons from a RGD-bearing Cholic Acid Derivative. Colloids Surf. B 2017, 159, 183-190. https://doi.org/10.1016/j.colsurfb.2017.07.084
  • 85. Bayati, S.; Bergquist, K.-E.; Zhu, K.; Nyström, B.; Pedersen, J. S.; Galantini, L.; Schillén, K., Mixed Micelles of Oppositely Charged Poly(N-isopropylacrylamide) Diblock Copolymers. J. Polym. Sci. B Polym. Phys. 2017, 55 (19), 1457-1469. https://doi.org/10.1002/polb.24403
  • 84. Lazzara, G.; Campbell, R. A.; Bayati, S.; Zhu, K.; Nyström, B.; Nylander, T.; Schillén, K., On the Formation of Inclusion Complexes at the Solid/Liquid Interface of Anchored Temperature-Responsive PNIPAAM Diblock Copolymers with γ-Cyclodextrin. Colloid Polym. Sci. 2017, 295 (8), 1327-1341. https://doi.org/10.1007/s00396-017-4052-6
  • 83. Gubitosi, M.; D’Annibale, A.; Schillén, K.; Olsson, U.; Pavel, N. V.; Galantini, L., On the Stability of Lithocholate Derivative Supramolecular Tubules. RSC Adv. 2017, 7, 512-517. https://doi.org/10.1039/C6RA26092F
  • 82. Galantini, L.; di Gregorio, M. C.; Gubitosi, M.; Travaglini, L.; Pavel, N. V.; Jover, A.; Meijide, F.; Tato, J. V.; Sennato, S.; Schillén, K.; De Santis, S.; Tranchini, F.; Masci, G., Supramolecular Assembly of a Thermoresponsive Steroidal Surfactant with an Oppositely Charged Thermoresponsive Block Copolymer. Phys. Chem. Phys. Chem. 2017, 19 (2), 1504-1515. https://doi.org/10.1039/C6CP05665B
  • 81. Bayati, S.; Haglund, C. A.; Pavel, N.; Galantini, L.; Schillén, K., Interaction between Bile Salt Sodium Glycodeoxycholate and PEO–PPO–PEO Triblock Copolymers in Aqueous Solution. RSC Adv. 2016, 6, 69313-69325. https://doi.org/10.1039/C6RA12514J
  • 80. Bayati, S.; Galantini, L.; Knudsen, K. D.; Schillén, K., Complexes of PEO-PPO-PEO Triblock Copolymer P123 and Bile Salt Sodium Glycodeoxycholate in Aqueous Solution: A Small Angle X-Ray and Neutron Scattering Investigation. Colloids Surf., A 2016, 504, 426-436. https://doi.org/10.1016/j.colsurfa.2016.05.096
  • 79. Travaglini, L.; Gubitosi, M.; di Gregorio, M. C.; D’Annibale, A.; Meijide, F.; Giustini, M.; Sennato, S.; Obiols-Rabasa, M.; Schillén, K.; Pavel, N. V., A Tryptophan-Substituted Cholic Acid: Expanding the Family of Labelled Biomolecules. Colloids Surf., A 2015, 483, 142-149. https://doi.org/10.1016/j.colsurfa.2015.03.033
  • 78. Murgia, S.; Falchi, A. M.; Meli, V.; Schillén, K.; Lippolis, V.; Monduzzi, M.; Rosa, A.; Schmidt, J.; Talmon, Y.; Bizzarri, R., Cubosome Formulations Stabilized by a Dansyl-Conjugated Block Copolymer for Possible Nanomedicine Applications. Colloids Surf., B 2015, 129, 87-94. https://doi.org/10.1016/j.colsurfb.2015.03.025
  • 77. Gubitosi, M.; Travaglini, L.; Di Gregorio, M. C.; Pavel, N. V.; Vázquez Tato, J.; Sennato, S.; Olsson, U.; Schillén, K.; Galantini, L., Tailoring Supramolecular Nanotubes by Bile Salt Based Surfactant Mixtures. Angew. Chem. Int. Ed. 2015, 54 (24), 7018-7021. https://doi.org/10.1002/ange.201500445
  • 76. Bayati, S.; Galantini, L.; Knudsen, K. D.; Schillén, K., Effects of Bile Salt Sodium Glycodeoxycholate on the Self-Assembly of PEO–PPO–PEO Triblock Copolymer P123 in Aqueous Solution. Langmuir 2015, 31 (50), 13519-13527. https://doi.org/10.1021/acs.langmuir.5b03828
  • 75. Yanez Arteta, M.; Campbell, R. A.; Watkins, E. B.; Obiols-Rabasa, M.; Schillén, K.; Nylander, T., Interactions of Small Dendrimers with Sodium Dodecyl Sulfate at the Air–Water Interface. J. Phys. Chem. B 2014, 118 (40), 11835-11848. https://doi.org/10.1021/jp507230m
  • 74. Janiak, J.; Tomšič, M.; Lundberg, D.; Olofsson, G.; Piculell, L.; Schillén, K., Soluble Aggregates in Aqueous Solutions of Polyion–Surfactant Ion Complex Salts and a Nonionic Surfactant. J. Phys. Chem. B 2014, 118 (32), 9745-9756. https://doi.org/10.1021/jp411701g (selected for journal cover)
  • 73. Gubitosi, M.; Travaglini, L.; D’Annibale, A.; Pavel, N. V.; Vazquez Tato, J.; Obiols-Rabasa, M.; Sennato, S.; Olsson, U.; Schillén, K.; Galantini, L., Sugar–Bile Acid-Based Bolaamphiphiles: From Scrolls to Monodisperse Single-Walled Tubules. Langmuir 2014, 30 (22), 6358-6366. https://doi.org/10.1021/la500908r
  • 72. Travaglini, L.; D’Annibale, A.; Di Gregorio, M. C.; Schillén, K.; Olsson, U.; Sennato, S.; Pavel, N. V.; Galantini, L., Between Peptides and Bile Acids: Self- Assembly of Phenylalanine Substituted Cholic Acids. J. Phys. Chem. B 2013, 117 (31), 9248-9257. https://doi.org/10.1021/jp405342v
  • 71. Percebom, A. M.; Janiak, J.; Schillén, K.; Piculell, L.; Loh, W., Micellization of Water-Soluble Complex Salts of an Ionic Surfactant with Hairy Polymeric Counterions. Soft Matter 2013, 9 (2), 515-526. https://doi.org/10.1039/C2SM26683K
  • 70. Janiak, J.; Piculell, L.; Schillén, K.; Lundberg, D., Responsive Release of Polyanions from Soluble Aggregates Formed with a Hydrolyzable Cationic Surfactant and a Nonionic Surfactant. Soft Matter 2013, 9 (15), 4103-4112. https://doi.org/10.1039/C3SM27315F
  • 69. di Gregorio, M. C.; Pavel, N. V.; Jover, A.; Meijide, F.; Tato, J. V.; Tellini, V. H. S.; Vargas, A. A.; Regev, O.; Kasavi, Y.; Schillén, K., pH Sensitive Tubules of a Bile Acid Derivative: A Tubule Opening by Release of Wall Leaves. Phys. Chem. Chem. Phys. 2013, 15 (20), 7560-7566. https://doi.org/10.1039/C3CP00121K
  • 68. Travaglini, L.; D’Annibale, A.; Schillén, K.; Olsson, U.; Sennato, S.; Pavel, N. V.; Galantini, L., Amino Acid-Bile Acid Based Molecules: Extremely Narrow Surfactant Nanotubes Formed by a Phenylalanine-Substituted Cholic Acid. Chem. Commun. 2012, 48, 12011-12013. https://doi.org/10.1039/C2CC36030F
  • 67. Lazzara, G.; Alfredsson, V.; Olofsson, G.; Zhu, K.; Nyström, B.; Schillén, K., Temperature-Responsive Inclusion Complex of Cationic PNIPAAM Diblock Copolymer and γ–Cyclodextrin. Soft Matter 2012, 8, 5043-5054. https://doi.org/10.1039/C2SM07252A
  • 66. Janiak, J.; Bayati, S.; Galantini, L.; Pavel, N. V.; Schillén, K., Nanoparticles with Bicontinuous Cubic Internal Structure Formed by Cationic and Nonionic Surfactants and an Anionic Polyelectrolyte. Langmuir 2012, 28 (48), 16536-16546. https://doi.org/10.1021/la303938k
  • 65. Lundberg, D.; Carnerup, A. M.; Janiak, J.; Schillén, K.; Miguel, M. D.; Lindman, B., Size and Morphology of Assemblies Formed by DNA and Lysozyme in Dilute Aqueous Mixtures. Phys. Chem. Phys. Chem. 2011, 13 (8), 3082-3091. https://doi.org/10.1039/C0CP01220C
  • 64. Long, Y. Y.; Philip, J. Y. N.; Schillén, K.; Liu, F.; Ye, L., Insight into Molecular Imprinting in Precipitation Polymerization Systems Using Solution NMR and Dynamic Light Scattering. J. Mol. Recognit. 2011, 24 (4), 619-630. https://doi.org/10.1002/jmr.1097
  • 63. Löf, D.; Schillén, K.; Nilsson, L., Flavonoids: Precipitation Kinetics and Interaction with Surfactant Micelles. J. Food Sci. 2011, 76 (3), N35-N39. https://doi.org/10.1111/j.1750-3841.2011.02103.x
  • 62. Janiak, J.; Piculell, L.; Olofsson, G.; Schillén, K., The Aqueous Phase Behavior of Polyion-Surfactant Ion Complex Salts Mixed with Nonionic Surfactants. Phys. Chem. Phys. Chem. 2011, 13 (8), 3126-3138. https://doi.org/10.1039/C0CP01031F
  • 61. Törnvall, U.; Hedström, M.; Schillén, K.; Hatti-Kaul, R., Structural, Functional and Chemical Changes in Pseudozyma Antarctica Lipase B on Exposure to Hydrogen Peroxide. Biochimie 2010, 92 (12), 1867-1875. https://doi.org/10.1016/j.biochi.2010.07.008
  • 60. Lundberg, D.; Carnerup, A. M.; Schillén, K.; Miguel, M. D.; Lindman, B., Phase Behavior and Coassembly of DNA and Lysozyme in Dilute Aqueous Mixtures: A Model Investigation of DNA-Protein Interactions. Langmuir 2010, 26 (5), 2986-2988. https://doi.org/10.1021/la904104w
  • 59. Balogh, J.; Olsson, U.; Pedersen, J. S.; Kaper, H.; Wennerström, H.; Schillén, K.; Miguel, M., Nonionic Microemulsions: Dependence of Oil-Chain Length and Active Component (Lidocaine). In Self-Organized Surfactant Structures, Tadros, T. F., Ed. John Wiley & Sons Ltd: Oxford, 2010, p 59-87. https://doi.org/10.1002/9783527632633.ch3
  • 58. Vaccaro, M.; Mangiapia, G.; Radulescu, A.; Schillén, K.; D'Errico, G.; Morelli, G.; Paduano, L., Colloidal Particles Composed of Amphiphilic Molecules Binding Gadolinium Complexes and Peptides as Tumor-Specific Contrast Agents in MRI: Physico-Chemical Characterization. Soft Matter 2009, 5 (13), 2504-2512. https://doi.org/10.1039/B820804B
  • 57. Löf, D.; Tomšič, M.; Glatter, O.; Fritz-Popovski, G.; Schillén, K., Structural Characterization of Nonionic Mixed Micelles Formed by C12EO6 Surfactant and P123 Triblock Copolymer. J. Phys. Chem. B 2009, 113 (16), 5478-5486. https://doi.org/10.1021/jp808442d
  • 56. Costa, T.; Schillén, K.; Miguel, M. D.; Lindman, B.; de Melo, J. S., Association of a Hydrophobically Modified Polyelectrolyte and a Block Copolymer Followed by Fluorescence Techniques. J. Phys. Chem. B 2009, 113 (18), 6194-6204. https://doi.org/10.1021/jp8093879
  • 55. Costa, T.; de Melo, J. S.; Miguel, M. D.; Lindman, B.; Schillén, K., Complex Formation between a Fluorescently-Labeled Polyelectrolyte and a Triblock Copolymer. J. Phys. Chem. B 2009, 113 (18), 6205-6214. https://doi.org/10.1021/jp8093885
  • 54. Burrows, H. D.; Tapia, M. J.; Fonseca, S. M.; Pradhan, S.; Scherf, U.; Silva, C. L.; Pais, A.; Valente, A. J. M.; Schillén, K.; Alfredsson, V.; Carnerup, A. M.; Tomsic, M.; Jamnik, A., Solubilization of Poly{1,4-Phenylene- 9,9-Bis(4-Phenoxy-Butylsulfonate) Fluorene-2,7-Diyl} in Water by Nonionic Amphiphiles. Langmuir 2009, 25 (10), 5545-5556. https://doi.org/10.1021/la8042044
  • 53. Ainalem, M. L.; Carnerup, A. M.; Janiak, J.; Alfredsson, V.; Nylander, T.; Schillén, K., Condensing DNA with Poly(Amido Amine) Dendrimers of Different Generations: Means of Controlling Aggregate Morphology. Soft Matter 2009, 5 (11), 2310-2320. https://doi.org/10.1039/B821629K
  • 52. Schillén, K.; Jansson, J.; Löf, D.; Costa, T., Mixed Micelles of a PEO-PPO-PEO Triblock Copolymer (P123) and a Nonionic Surfactant (C12EO6) in Water. A Dynamic and Static Light Scattering Study. J. Phys. Chem. B 2008, 112 (18), 5551-5562. https://doi.org/10.1021/jp074832w
  • 51. Gaweda, S.; Moran, M. C.; Pais, A.; Dias, R. S.; Schillén, K.; Lindman, B.; Miguel, M. G., Cationic Agents for DNA Compaction. J. Colloid Interface Sci. 2008, 323 (1), 75-83. https://doi.org/10.1016/j.jcis.2008.04.006
  • 50. Cardenas, M.; Schillén, K.; Alfredsson, V.; Duan, R. D.; Nyberg, L.; Amebrant, T., Solubilization of Sphingornyelin Vesicles by Addition of a Bile Salt. Chem. Phys. Lipids 2008, 151 (1), 10-17. https://doi.org/10.1016/j.chemphyslip.2007.09.002
  • 49. Vaccaro, M.; Accardo, A.; D'Errico, G.; Schillén, K.; Radulescu, A.; Tesauro, D.; Morelli, G.; Paduano, L., Peptides and Gd Complexes Containing Colloidal Assemblies as Tumor-Specific Contrast Agents in MRI: Physicochemical Characterization. Biophys. J. 2007, 93 (5), 1736-1746. https://doi.org/10.1529/biophysj.107.107417
  • 48. Torres, M. F.; Gonzalez, J. M.; Rojas, M. R.; Muller, A. J.; Saez, A. E.; Löf, D.; Schillén, K., Effect of Ionic Strength on the Rheological Behavior of Aqueous Cetyltrimethylammonium p-Toluene Sulfonate Solutions. J. Colloid Interface Sci. 2007, 307 (1), 221-228. https://doi.org/10.1016/j.jcis.2006.11.002
  • 47. Tesauro, D.; Accardo, A.; Gianolio, E.; Paduano, L.; Teixeira, J.; Schillén, K.; Aime, S.; Morelli, G., Peptide Derivatized Lamellar Aggregates as Target-Specific MRI Contrast Agents. Chem. Bio. Chem 2007, 8 (8), 950-955. https://doi.org/10.1002/cbic.200700077
  • 46. Örberg, M. L.; Schillén, K.; Nylander, T., Dynamic Light Scattering and Fluorescence Study of the Interaction between Double-Stranded DNA and Poly(Amido Amine) Dendrimers. Biomacromolecules 2007, 8 (5), 1557-1563. https://doi.org/10.1021/bm061194z
  • 45. Örberg, M. L.; Nylander, T.; Schillén, K., Characterisation of the Aggregate Formation between Linear DNA and Poly(Amidoamine) Dendrimers. Biophys. J. 2007, Suppl. S, 44A. ISSN: 0006-3495
  • 44. Löf, D.; Schillén, K.; Torres, M. F.; Muller, A. J., Rheological Study of the Shape Transition of Block Copolymer-Nonionic Surfactant Mixed Micelles. Langmuir 2007, 23 (22), 11000-11006. https://doi.org/10.1021/la701818y
  • 43. Löf, D.; Schillén, K.; Jönsson, B.; Evilevitch, A., Forces Controlling the Rate of DNA Ejection from Phage Lambda. J. Mol. Biol. 2007, 368 (1), 55-65. https://doi.org/10.1016/j.jmb.2007.01.076
  • 42. Löf, D.; Schillén, K.; Jönsson, B.; Evilevitch, A., Dynamic and Static Light Scattering Analysis of DNA Ejection from the Phage Lambda. Phys. Rev. E 2007, E76, 011914. https://doi.org/10.1103/PhysRevE.76.011914
  • 41. Löf, D.; Niemiec, A.; Schillén, K.; Loh, W.; Olofsson, G., A Calorimetry and Light Scattering Study of the Formation and Shape Transition of Mixed Micelles of EO20PO68EO20 Triblock Copolymer (P123) and Nonionic Surfactant (C12EO6). J. Phys. Chem. B 2007, 111 (21), 5911-5920. https://doi.org/10.1021/jp071101n
  • 40. de Melo, J. S. S.; Costa, T.; Oliveira, N.; Schillén, K., Fluorescence Studies on the Interaction between Pyrene-Labelled Poly(Acrylic Acid) and Cyclodextrins. Polymer Int. 2007, 56 (7), 882-899. https://doi.org/10.1002/pi.2219
  • 39. Accardo, A.; Tesauro, D.; Morelli, G.; Gianolio, E.; Aime, S.; Vaccaro, M.; Mangiapia, G.; Paduano, L.; Schillén, K., High-Relaxivity Supramolecular Aggregates Containing Peptides and Gd Complexes as Contrast Agents in MRI. J. Biol. Inorg. Chem. 2007, 12 (2), 267-276. https://doi.org/10.1007/s00775-006-0186-6
  • 38. Vaccaro, M.; Accardo, A.; Tesauro, D.; Mangiapia, G.; Löf, D.; Schillén, K.; Söderman, O.; Morelli, G.; Paduano, L., Supramolecular Aggregates of Amphiphilic Gadolinium Complexes as Blood Pool MRI/MRA Contrast Agents: Physicochemical Characterization. Langmuir 2006, 22 (15), 6635-6643. https://doi.org/10.1021/la053500k
  • 37. Santos, O.; Nylander, T.; Schillén, K.; Paulsson, M.; Trägårdh, C., Effect of Surface and Bulk Solution Properties on the Adsorption of Whey Protein onto Steel Surfaces at High Temperature. J. Food Eng. 2006, 73 (2), 174-189. https://doi.org/10.1016/j.jfoodeng.2005.01.018
  • 36. Cardenas, M.; Barauskas, J.; Schillén, K.; Brennan, J. L.; Brust, M.; Nylander, T., Thiol-Specific and Nonspecific Interactions between DNA and Gold Nanoparticles. Langmuir 2006, 22 (7), 3294-3299. https://doi.org/10.1021/la0530438
  • 35. Samoshina, Y.; Nylander, T.; Claesson, P.; Schillén, K.; Iliopoulos, I.; Lindman, B., Adsorption and Aggregation of Cationic Amphiphilic Polyelectrolytes on Silica. Langmuir 2005, 21 (7), 2855-2864. https://doi.org/10.1021/la047311y
  • 34. Löf, D.; Schillén, K.; Olofsson, G.; Lindman, B.; Loh, W.; Niemiec, A.; Torres, M.; Müller, A. J., The Shape Transition of Block Copolymer/Nonionic Surfactant Complexes. In XI Coloquio Venezolano de Polímeros, SABER-ULA Universidad de Los Andes Venezuela: Caracas, 2005; 63-64.
  • 33. Jansson, J.; Schillén, K.; Nilsson, M.; Söderman, O.; Fritz, G.; Bergmann, A.; Glatter, O., Small-Angle X-Ray Scattering, Light Scattering, and NMR Study of PEO-PPO-PEO Triblock Copolymer/Cationic Surfactant Complexes in Aqueous Solution. J. Phys. Chem. B 2005, 109 (15), 7073-7083. https://doi.org/10.1021/jp0468354
  • 32. Costa, T.; Schillén, K.; Miguel, M. G.; Lindman, B.; de Melo, J. S., Study of the Interaction between a Polyelectrolyte Randomly Labeled with Pyrene and a PEO-PPO-PEO Triblock Copolymer Using Fluorescence and Dynamic Light Scattering. In Coloides e Interfases, Velazques, M. M.; Merchan, M. D., Eds. Ediciones Universidad de Salamanca: Salamanca, 2005; 313-319.
  • 31. Costa, T.; Miguel, M. G.; Lindman, B.; Schillén, K.; Lima, J. C.; de Melo, J. S., Self-Assembly of a Hydrophobically Modified Naphthalene-Labeled Poly(Acrylic Acid) Polyelectrolyte in Water: Organic Solvent Mixtures Followed by Steady-State and Time-Resolved Fluorescence. J. Phys. Chem. B 2005, 109 (8), 3243-3251. https://doi.org/10.1021/jp046589w
  • 30. Costa, T.; Miguel, M. D.; Lindman, B.; Schillén, K.; de Melo, J. S. S., Dynamics and Energetics of the Self-Assembly of a Hydrophobically Modified Polyelectrolyte: Naphthalene-Labeled Poly(Acrylic Acid). J. Phys. Chem. B 2005, 109 (23), 11478-11492. https://doi.org/10.1021/jp050236v
  • 29. Cardenas, M.; Schillén, K.; Pebalk, D.; Nylander, T.; Lindman, B., Interaction between DNA and Charged Colloids Could Be Hydrophobically Driven. Biomacromolecules 2005, 6 (2), 832-837. https://doi.org/10.1021/bm049422h
  • 28. Bryskhe, K.; Schillén, K.; Olsson, U.; Yaghmur, A.; Glatter, O., Formation of Internally Nanostructured Triblock Copolymer Particles. Langmuir 2005, 21 (19), 8597-8600. https://doi.org/10.1021/la051157d
  • 27. Jansson, J.; Schillén, K.; Olofsson, G.; da Silva, R. C.; Loh, W., The Interaction between PEO-PPO-PEO Triblock Copolymers and Ionic Surfactants in Aqueous Solution Studied Using Light Scattering and Calorimetry. J. Phys. Chem. B 2004, 108 (1), 82-92. https://doi.org/10.1021/jp030792u
  • 26. Cardenas, M.; Schillén, K.; Nylander, T.; Jansson, J.; Lindman, B., DNA Compaction by Cationic Surfactant in Solution and at Polystyrene Particle Solution Interfaces: A Dynamic Light Scattering Study. Phys. Chem. Phys. Chem. 2004, 6 (7), 1603-1607. https://doi.org/10.1039/B310798A
  • 25. Bryskhe, K.; Jansson, J.; Topgaard, D.; Schillén, K.; Olsson, U., Spontaneous Vesicle Formation in a Block Copolymer System. J. Phys. Chem. B 2004, 108 (28), 9710-9719. https://doi.org/10.1021/jp031313u
  • 24. Nilsson, A.; Neves-Petersen, M. T.; Johansson, H. O.; Jansson, J.; Schillén, K.; Tjerneld, F.; Petersen, S. B., Tryptophan-Tagged Cutinase Studied by Steady State Fluorescence for Understanding of Tag Interactions in Aqueous Two-Phase Systems. Biochim. Biophys. Acta, Proteins Proteomics 2003, 1646 (1-2), 57-66. https://doi.org/10.1016/S1570-9639(02)00550-2
  • 23. de Melo, J. S.; Costa, T.; Miguel, M. D.; Lindman, B.; Schillén, K., Time-Resolved and Steady-State Fluorescence Studies of Hydrophobically Modified Water-Soluble Polymers. J. Phys. Chem. B 2003, 107 (46), 12605-12621. https://doi.org/10.1021/jp0346054
  • 22. da Silva, R. C.; Olofsson, G.; Schillén, K.; Loh, W., Influence of Ionic Surfactants on the Aggregation of Poly(Ethylene Oxide)-Poly(Propylene Oxide)- Poly(Ethylene Oxide) Block Copolymers Studied by Differential Scanning and Isothermal Titration Calorimetry. J. Phys. Chem. B 2002, 106 (6), 1239-1246. https://doi.org/10.1021/jp012729f
  • 21. Bryskhe, K.; Schillén, K.; Löfroth, J. E.; Olsson, U., Lipid-Block Copolymer Immiscibility. Phys. Chem. Phys. Chem. 2001, 3 (7), 1303-1309. https://doi.org/10.1039/B009487K
  • 20. Schillén, K.; Anghel, D. F.; Miguel, M. D.; Lindman, B., Association of Naphthalene-Labeled Poly(Acrylic Acid) and Interaction with Cationic Surfactants. Fluorescence Studies. Langmuir 2000, 16 (26), 10528-10539. https://doi.org/10.1021/la000943+
  • 19. Schillén, K.; Yekta, A.; Ni, S. R.; Farinha, J. P. S.; Winnik, M. A., Characterization of Polyisoprene-B-Poly(Methyl Methacrylate) Diblock Copolymer Micelles in Acetonitrile. J. Phys. Chem. B 1999, 103 (43), 9090-9103. https://doi.org/10.1021/jp990251y
  • 18. Schillén, K.; Yekta, A.; Ni, S.; Winnik, M. A., Characterization by Fluorescence Energy Transfer of the Core of Polyisoprene-Poly(Methyl Methacrylate) Diblock Copolymer Micelles. In Trends in Colloid and Interface Science XIII. Tezak, D.; Martinis, M., Eds. 1999; 112, p 45-48. https://doi.org/10.1007/3-540-48953-3_10
  • 17. Schillén, K.; Bryskhe, K.; Mel'nikova, Y. S., Vesicles Formed from a Poly(Ethylene Oxide)-Poly(Propylene Oxide)-Poly(Ethylene Oxide) Triblock Copolymer in Dilute Aqueous Solution. Macromolecules 1999, 32 (20), 6885-6888. https://doi.org/10.1021/ma9908144
  • 16. Farinha, J. P. S.; Schillén, K.; Winnik, M. A., Interfaces in Self-Assembling Diblock Copolymer Systems: Characterization of Poly(Isoprene-B-Methyl Methacrylate) Micelles in Acetonitrile. J. Phys. Chem. B 1999, 103 (13), 2487-2495. https://doi.org/10.1021/jp9843858
  • 15. Schillén, K.; Yekta, A.; Ni, S. R.; Winnik, M. A., Characterization by Fluorescence Energy Transfer of the Core of Polyisoprene- Poly(Methylmethacrylate) Diblock Copolymer Micelles. Strong Segregation in Acetonitrile. Macromolecules 1998, 31 (1), 210-212. https://doi.org/10.1007/3-540-48953-3_10
  • 14. Kitaev, V.; Schillén, K.; Kumacheva, E., Supramolecular Structures of Poly(Gamma-Benzyl-L-Glutamate) Self-Assembled on Mica Surface. J. Polym. Sci. Part B: Polym. Phys. 1998, 36 (9), 1567-1577.
  • 13. Fielden, M. L.; Claesson, P. M.; Schillén, K., Investigation of a 31% Charged Cationic Polyelectrolyte Interacting with Sodium Dodecyl Sulfate in Bulk Solution and as a Preadsorbed Layer on Mica. Low Ionic Strength. Langmuir 1998, 14 (19), 5366-5375. https://doi.org/10.1021/la980456i
  • 12. Schillén, K.; Claesson, P. M.; Malmsten, M.; Linse, P.; Booth, C., Properties of Poly(Ethylene Oxide)-Poly(Butylene Oxide) Diblock Copolymers at the Interface between Hydrophobic Surfaces and Water. J. Phys. Chem. B 1997, 101 (21), 4238-4252. https://doi.org/10.1021/jp963193e
  • 11. Jorgensen, E. B.; Hvidt, S.; Brown, W.; Schillén, K., Effects of Salts on the Micellization and Gelation of a Triblock Copolymer Studied by Rheology and Light Scattering. Macromolecules 1997, 30 (8), 2355-2364. https://doi.org/10.1021/ma9616322
  • 10. Schillén, K.; Brown, W.; Johnsen, R. M., Micellar Sphere-to-Rod Transition in an Aqueous Triblock Copolymer System. A Dynamic Light Scattering Study of Translational and Rotational Diffusion. Macromolecules 1994, 27 (17), 4825-4832. https://doi.org/10.1021/ma00095a025
  • 9. Hvidt, S.; Jorgensen, E. B.; Brown, W.; Schillén, K., Micellization and Gelation of Aqueous Solutions of a Triblock Copolymer Studied by Rheological Techniques and Scanning Calorimetry. J. Phys. Chem. 1994, 98 (47), 12320-12328. https://doi.org/10.1021/j100098a030
  • 8. Glatter, O.; Scherf, G.; Schillén, K.; Brown, W., Characterization of a Poly(Ethylene Oxide)-Poly(Propylene Oxide) Triblock Copolymer (EO27-PO39-EO27) in Aqueous Solution. Macromolecules 1994, 27 (21), 6046-6054. https://doi.org/10.1021/ma00099a017
  • 7. Glatter, O.; Schillén, K.; Scherf, G., Formation of Micelles and Gels from Block Copolymers in Water Followed by Ultra-Sound Velocimetry and Complex Densitometry. In Trends in Colloid and Interface Science VII, Springer, Laggner, P.; Glatter, O., Eds., Progr. Polym. Sci., 1993, 93, 251-252. https://doi.org/10.1007/BFb0118536
  • 6. Schillén, K.; Glatter, O.; Brown, W., Characterization of a PEO-PPO-PEO Copolymer System. In Trends in Colloid and Interface Science VII, Springer, Laggner, P.; Glatter, O., Eds., Progr. Polym. Sci., 1993, 93, 66-71. https://doi.org/10.1007/BFb0118476
  • 5. Schillén, K.; Brown, W.; Konak, C., Aggregation of a Poly(Ethylene Oxide)-Poly(Propylene Oxide)-Poly(Ethylene Oxide) Triblock Copolymer in Aqueous Solution Studied Using Rayleigh-Brillouin and Dynamic Light Scattering. Macromolecules 1993, 26 (14), 3611-3614. https://doi.org/10.1021/ma00066a020
  • 4. Brown, W.; Schillén, K.; Johnsen, R.; Konak, C.; Dvoranek, L., Brillouin Light Scattering from Poly(Methyl Methacrylate)/Toluene Concentrated Solutions. Macromolecules 1992, 25 (2), 802-805. https://doi.org/10.1021/ma00028a046
  • 3. Brown, W.; Schillén, K.; Hvidt, S., Triblock Copolymers in Aqueous Solution Studied by Static and Dynamic Light Scattering and Oscillatory Shear Measurements. Influence of Relative Block Sizes. J. Phys. Chem. 1992, 96 (14), 6038-6044. https://doi.org/10.1021/j100193a072
  • 2. Brown, W.; Schillén, K.; Almgren, M.; Hvidt, S.; Bahadur, P., Micelle and Gel Formation in a Poly(Ethylene Oxide)-Poly(Propylene Oxide)-Poly(Ethylene Oxide) Triblock Copolymer in Water Solution. Dynamic and Static Light Scattering and Oscillatory Shear Measurements. J. Phys. Chem. 1991, 95 (4), 1850-1858. https://doi.org/10.1021/j100157a064
  • 1. Brown, W.; Johansson, K.; Almgren, M., Threadlike Micelles from Cetyltrimethylammonium Bromide in Aqueous Sodium Naphthalenesulfonate Solutions Studied by Static and Dynamic Light Scattering. J. Phys. Chem. 1989, 93 (15), 5888-5894. https://doi.org/10.1021/j100352a047
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