Physical Chemistry

Lund University

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Emma Sparr, Professor

Academic background

2011: Professor in Physical Chemistry-Colloidal Biology, Lund University 
2009: Docent in Physical Chemistry, Lund University 
2004- 2011: Assistant Professor, Physical Chemistry. Financed by VR
 Postdoc at the Dept. Biochemistry of Membranes, Utrecht University. 
 Postdoc at the Dept Pharmacy, Uppsala University
 PhD in Physical Chemistry, Lund University
1996: MSc in Chemistry, Lund university & University of Cambridge

Programs and Research Centers

• Member of the Wallenberg research project "Physical chemistry of peptide-lipid co-assembly: from lipid-rich to peptide-rich" (2015-2020)
• Member in the Young Academy of Sweden (2011-2016)
• Member of the Wallenberg research project "Anisotropic forces in colloidal systems" (2015-2020)
• Partner and Director of the Linnaeus Research Center Organizing Molecular Matter (OMM) (2006-2016)
• Associated partner in Multipark - a strategic research area at Lund university (2009-)
• Participating in the programme Future Research Leaders, a project funded by the Swedish Foundation for Strategic Research (SSF) (2008-2013

Selected publications

Complete list

E.H. Mujumdar, Q.D. Pham, D. Topgaard, E. Sparr. Skin Hydration: Interplay between molecular dynamics, structure and water uptake in the stratum corneum. Sci Reports (2017). In press

J. M. Andersson, C. Grey, M. Larsson, T.M. Ferreira, E. Sparr. Effect of cholesterol on the molecular structure and transitions in a clinical-grade lung surfactant extract. PNAS (2017) doi: 10.1073/pnas.1701239114

Q.D. Pham, D. Topgaard, E. Sparr. Tracking solvents in the skin- Molecular mobility of solvents, lipids and protein in intact stratum corneum. PNAS (2017) 114, E112-E121

K. Roger, M. Liebi, J. Heimdal, Q.D. Pham, E. Sparr. Controlling evaporation through self-assembly. PNAS (2016) 113, 10275
Highligted in Nature Physics, Swedish public service news, SR Vetenskapsradion (Sept 22, ca 02:30) and SVT science news.
Link to LU press release (in Swedish) and English translation

R. Gaspar, G. Meisl, A. K. Buell, L. Young, C.F. Kaminski, T.P.J. Knowles, E. Sparr, S. Linse. Secondary nucleation of monomers on fibril surface dominates a-synuclein aggregation and provides autocatalytic amyloid amplification. Quart. Rev. Biophysics (2016) 50, e6

C. Galvagnion , J.W.P. Brown  , M.M. Ouberai, P. Flagmeier , M. Vendruscolo, A.K. Buell, E. Sparr,  C.M. Dobson. The chemical properties of lipids strongly a ffect the kinetics of the membrane-induced aggregation of alpha-synuclein. PNAS (2016) 113, 7065

Q.D. Pham, S. Björklund, J. Engblom, D. Topgaard, E. Sparr. Chemical penetration enhancers in stratum corneum — Relation between molecular effects and barrier function. J Controlled Release (2016) 232, 175-187

A. Dabkowska, A. Michanel, L. Jaeger, M. Rabe, F. Höök, T. Nylander, E. Sparr. Assembly of RNA nanostructures on supported lipid bilayers. Nanoscale (2015) 7, 583–596

M. Grey, C. Dunning, R. Gaspar, C. Grey, P. Brundin, E. Sparr, S. Linse. Acceleration of a-synuclein aggregation by exosomes. J Biol Chem (2015) 290, 2969–2982
Recommended  in F1000Prime as being of special significance in its field

S. Björklund, J.M. Andersson, Q.D. Pham, A. Nowacka, D. Topgaard, E. Sparr. Stratum corneum molecular mobility in the presence of natural moisturizers. Soft Matter (2014) 10, 4535-4546
Hot article April on Soft matter blog
Highlighted in Chemistry World article "Redefining moisteriser"

T. Mokhtari, Q.D. Pham, C. Hirst, B.M.D. O'Driscoll, T. Nylander, K.J. Edler, E. Sparr. Controlling interfacial film formation in polymer-surfactant systems by changing the vapor phase. Langmuir (2014) 111, 7671-7677

A.K. Buell, C. Galvagnion, R. Gaspar, E. Sparr, M. Vendruscolo, T.P.J. Knowles S. Linse, C.M. Dobson Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation. Proc Natl Acad Sci USA (2014) 

E. Hellstrand, M. Grey, M-L- Ainalem, J. Ankner, T. Forsyth, G. Fragneto, M. Haetlein, M.T. Dauvergne, H. Nilsson, P. Brundin, S. Linse, T. Nylander, E. Sparr. Adsorption of a-synuclein to supported lipid bilayers - positioning and role of electrostatics. ACS Chem Neurosci (2013) 4, 1339-1351

S. Björklund, A. Nowacka, J.A. Bouwstra, E. Sparr, D. Topgaard. Characterization of stratum corneum molecular dynamics by natural-abundance 13C solid-state NMR. PLoS ONE (2013). 8, e61889

E. Sparr, D. Millecamp, M .Isoir, V. Burnier, Å. Larsson, B. Cabane. Controlling the hydration of the skin though the application of occluding barrier creams JRS Interface (2013) 10, 20120788

E. Hellstrand, A. Nowacka, D. Topgaard, S. Linse, E. Sparr. Membrane Lipid Co-Aggregation with α-Synuclein Fibrils. PLoS ONE (2013) e77235

A. Michanek, T. Nylander, E. Sparr. ssRNA base pairing at a bilayer interface can be controlled by acyl chain order. Soft Matter (2012) 8, 10428

A. Nowacka, S. Douezan, L. Wadsö, D. Topgaard, and E. Sparr, Small polar molecules like glycerol and urea can preserve the fluidity of lipid bilayers under dry conditions, Soft Matter (2012) 8, 1482

A. Michanek, M. Yanez, H. Wacklin, A. Hughes, T. Nylander, E. Sparr, RNA and DNA Association to Zwitterionic and Charged Monolayers at the Air−Liquid Interface Langmuir (2012) 28, 9692

C. Åberg, E. Sparr, H. Wennerström, Lipid Phase Behaviour under Steady-State Conditions (2012) Faraday Discussions. I61, 151-161

M. Grey, P. Brundin, H. Nilsson, S. Linse, E. Sparr; Membrane interaction of a-synucluein in different aggregation states, J. Parkinson Disease (2011) 1, 359

E. Sparr, H. Wennerström; Interlamellar forces and the thermodynamic characterization of lamellar phospholipid systems. Current opinion in Colloid and Interface Science (2011) 16, 561

S. Björklund, J. Engblom, K. Thuresson, E. Sparr; A water gradient can be used to regulate drug transport across skin. J. Control Release (2010) 143, 191

C. Åberg, E. Sparr, M. Larsson, H. Wennerström; A Theoretical Study of Diffusional Transport over the Alveolar Surfactant Layer. Journal of the Royal Society Interface (2010) 7, 1403

E. Sparr, C. Åberg, P. Nilsson, H. Wennerström; Diffusional transport in responding lipid membranes. Soft Matter (2009) 25, 3225

C- Åberg, E. Sparr, K.J. Edler, H.Wennerström; Nonequilibrium Phase Transformations at the Air−Liquid Interface. Langmuir (2009) 25, 12177

E. Sparr, M.F.M. Engel, D.V. Sakharov, M. Sprong, J. Jacobs,  B. de Kruijff, J.W.M. Höppener, J. A. KillianIslet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers FEBS Lett (2004) 577, 117


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