Physical Chemistry

Lund University

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Emma Sparr, Professor

Academic background

2011: Professor in Physical Chemistry-Colloidal Biology, Lund University 
2009: Docent in Physical Chemistry, Lund University 
2004- 2011: Assistant Professor, Physical Chemistry. Financed by VR
 Postdoc at the Dept. Biochemistry of Membranes, Utrecht University. 
 Postdoc at the Dept Pharmacy, Uppsala University
 PhD in Physical Chemistry, Lund University
1996: MSc in Chemistry, Lund university & University of Cambridge

Programs and Research Centers

• Member of the Wallenberg research project "Physical chemistry of peptide-lipid co-assembly: from lipid-rich to peptide-rich" (2015-2020)
• Member in the Young Academy of Sweden (2011-2016)
• Member of the Wallenberg research project "Anisotropic forces in colloidal systems" (2015-2020)
• Partner and Director of the Linnaeus Research Center Organizing Molecular Matter (OMM) (2006-2016)
• Associated partner in Multipark - a strategic research area at Lund university (2009-)
• Participating in the programme Future Research Leaders, a project funded by the Swedish Foundation for Strategic Research (SSF) (2008-2013

Selected Publications

complete list

Q.D. Pham, A. Wolde-Kidan, A. Gupta, E. Schneck, R. Netz, E. Sparr
Effects of Urea and TMAO on Lipid Self-Assembly under Osmotic Stress Conditions
J. Phys Chem B (2018) In press (selected for journal cover)

J. Habchi, S. Chia, C. Galvagnion, T. C. T. Michaels, M. Bellaiche, F. S. Ruggeri, M. Sanguanini, I. Idini, J. R. Kumita, E. Sparr, S. Linse, C. M. Dobson, T. P. J. Knowles, M. Vendruscolo. Cholesterol catalyses Ab42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nature Chemistry (2018) In press

K. Roger, E. Sparr, H. Wennerström. Evaporation, diffusion and self-assembly at drying interfaces. PCCP (2018) In press

E.H. Mujumdar, Q.D. Pham, D. Topgaard, E. Sparr. Skin Hydration: Interplay between molecular dynamics, structure and water uptake in the stratum corneum. Sci Reports (2017) 7, 15712

J. M. Andersson, C. Grey, M. Larsson, T.M. Ferreira, E. Sparr. Effect of cholesterol on the molecular structure and transitions in a clinical-grade lung surfactant extract. PNAS (2017) 114, E3592-E3601

Q.D. Pham, D. Topgaard, E. Sparr. Tracking solvents in the skin- Molecular mobility of solvents, lipids and protein in intact stratum corneum. PNAS (2017) 114, E112-E121

K. Roger, M. Liebi, J. Heimdal, Q.D. Pham, E. Sparr. Controlling evaporation through self-assembly. PNAS (2016) 113, 10275 

C. Galvagnion , J.W.P. Brown  , M.M. Ouberai, P. Flagmeier , M. Vendruscolo, A.K. Buell, E. Sparr,  C.M. Dobson. The chemical properties of lipids strongly a ffect the kinetics of the membrane-induced aggregation of alpha-synuclein. PNAS (2016) 113, 7065-70 

A. Dabkowska, A. Michanel, L. Jaeger, M. Rabe, F. Höök, T. Nylander, E. Sparr. Assembly of RNA nanostructures on supported lipid bilayers. Nanoscale (2015) 7, 583–596 

M. Grey, C. Dunning, R. Gaspar, C. Grey, P. Brundin, E. Sparr, S. Linse. Acceleration of a-synuclein aggregation by exosomes. J Biol Chem (2015) 290, 2969–2982 

S. Björklund, J.M. Andersson, Q.D. Pham, A. Nowacka, D. Topgaard, E. Sparr. Stratum corneum molecular mobility in the presence of natural moisturizers. Soft Matter (2014) 10, 4535-4546 

A.K. Buell, C. Galvagnion, R. Gaspar, E. Sparr, M. Vendruscolo, T.P.J. Knowles S. Linse, C.M. Dobson Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation. Proc Natl Acad Sci USA (2014) 111. 7671-7677 

E. Hellstrand, A. Nowacka, D. Topgaard, S. Linse, E. Sparr. Membrane Lipid Co-Aggregation with α-Synuclein Fibrils. PLoS ONE (2013) e61889

53. E. Hellstrand, M. Grey, M-L- Ainalem, J. Ankner, T. Forsyth, G. Fragneto, M. Haetlein, M.T. Dauvergne, H. Nilsson, P. Brundin, S. Linse, T. Nylander, E. Sparr. Adsorption of a-synuclein to supported lipid bilayers - positioning and role of electrostatics. ACS Chem Neurosci (2013) 4, 1339-1351 

S. Björklund, A. Nowacka, J.A. Bouwstra, E. Sparr, D. Topgaard. Characterization of stratum corneum molecular dynamics by natural-abundance 13C solid-state NMR. PLOS One (2013). 8, e61889 

C. Åberg, E. Sparr, H. Wennerström, Lipid Phase Behaviour under Steady-State Conditions (2012) Faraday Discussions. I61, 151-161 

A. Nowacka, S. Douezan, L. Wadsö, D. Topgaard, and E. Sparr, Small polar molecules like glycerol and urea can preserve the fluidity of lipid bilayers under dry conditions, Soft Matter (2012) 8, 1482 

 E. Sparr, M.F.M. Engel, D.V. Sakharov, M. Sprong, J. Jacobs,  B. de Kruijff, J.W.M. Höppener, J. A. Killian. Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. FEBS Lett (2004) 577, 117–120 

E. Sparr, H. Wennerström. Responding Binary Phospholipid Membranes - Interplay between Hydration and Permeability. Biophys. J. (2001) 81, 1014-1028 

N. Markova, E. Sparr, L. Wadsö. Applications of the Double Twin Isothermal Microcalorimeter – Phase Transformations and Clay Swelling.  Thermochim. Acta (2001) 374, 93-104 




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