Ulf Olsson
Professor
Influence of Salt on the Self-Assembly of Two Model Amyloid Heptapeptides
Author
Summary, in English
We study the effects of NaCl on the self-assembly of AAKLVFF and beta A beta AKLVFF in solution. Both AAKLVFF and beta A beta AKLVFF self-assemble into twisted fibers in aqueous solution. The addition of NaCl to aqueous solutions of AAKLVFF produces large crystal-like nanotapes which eventually precipitate. In contrast, highly twisted fibrils were observed for beta A beta AKLVFF solutions at low salt concentration, while a coexistence of highly twisted fibers and nanotubes was observed for beta A beta AKLVFF at high salt concentration. The self-assembled structures observed for beta A beta AKLVFF in NaCl solutions were ascribed to the progressive screening of the beta A beta AKLVFF surface charge caused by the addition of salt.
Department/s
- Physical Chemistry
Publishing year
2010
Language
English
Pages
8002-8008
Publication/Series
The Journal of Physical Chemistry Part B
Volume
114
Issue
23
Document type
Article
Publisher
The American Chemical Society (ACS)
Topic
- Physical Chemistry (including Surface- and Colloid Chemistry)
Status
Published
ISBN/ISSN/Other
- ISSN: 1520-5207