Peter Jönsson is Senior Lecturer and Docent at the Division of Physical Chemistry, Lund University, since 2015, with a research focus in biomolecular interactions at interfaces. His research spans several different areas such as chemistry, physics and biology, but can more specifically be divided into the following main topics:
- Development of novel biophysical tools and methods to study and manipulate molecules on the surface of cells.
- Investigation of the organisation and function of key membrane proteins in the initiation of an adaptive immune response.
- Physical chemistry of peptide-lipid co-assembly: from lipid-rich to peptide-rich
A common factor in all these projects is the use of advanced fluorescence microscopy to study the mobility and distribution of molecules down to the single molecule level.
Before moving to Lund, Peter did a three year postdoctoral stay in Cambridge, UK, where he worked with Prof. David Klenerman on developing new tools to study biological processes on the surface of cells. During this time he also had the opportunity to collaborate with Prof. Yuri Korchev’s group at Imperial College London, UK, on using nm- to µm-sized pipettes to manipulate and stimulate molecules on cells. Peter was introduced during his final two years in Cambridge to the field of adaptive immunity by Prof. Simon Davis in Oxford, UK. Together with researchers in Prof. Klenerman’s group and in Prof. Davis’ group he has investigated how molecules on the surface of cells in the adaptive immune system behave and organize at the start of an immune response. Peter graduated as PhD in Physics from Chalmers, Sweden, in 2010 under the supervision of Prof. Fredrik Höök, where he got to work with artificial model systems of a cell membrane, so called supported lipid bilayers, and with fluorescence microscopy, two techniques that have become central for his work since then.
- 2015 - 2020: Victoria Junghans
- 2017 - 2020: Mohammad Arif Kamal
- Chouliara M, Junghans V, Dam T, Santos AM, Davis SJ, Jönsson P, "Single Cell Measurements of Two-Dimensional Binding Affinity Across Cell Contacts" Biophys. J., doi.org/10.1016/j.bpj.2021.10.010 (2021).
- Dam T, Junghans V, Humphrey J, Chouliara M, Jönsson P, "Calcium Signaling in T Cells Is Induced by Binding to Nickel-Chelating Lipids in Supported Lipid Bilayers" Front. Physiol., 11, 613367 (2021).
- Junghans V, et al., "Effects of a local auxiliary protein on the two-dimensional affinity of a TCR–peptide MHC interaction" J. Cell Sci., 133, jcs245985 (2020).
- Junghans V, Santos AM, Lui Y, Davis SJ, Jönsson P, "Dimensions and interactions of large T-cell surface proteins" Front. Immunol., 9, 2215 (2018).
- Junghans V, et al., "Hydrodynamic trapping measures the interaction between membrane-associated molecules" Sci. Rep., 8, 12479 (2018).
- Jönsson P, et al., "Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions" Proc. Natl. Acad. Sci. U.S.A., 113, 5682-5687 (2016).
- Jönsson P, Jonsson MP, Tegenfeldt JO, Höök F, "A Method Improving the Accuracy of Fluorescence Recovery after Photobleaching Analysis", Biophys. J.,95, 5334-5348 (2008). A MATLAB program implementing the method for FRAP analysis can be downloaded from Matlab Central.
For a list of all publications see Peter's ORCID.
- 2018: Senior Lecturer, Div. of Physical Chemistry, Lund University
- 2016: Docent in Physical Chemistry, Lund University
- 2015: Associate Senior University Lecturer, Div. of Physical Chemistry, Lund University
- 2014 – 2015: Researcher, Div. of Physical Chemistry, Lund University
- 2013 – 2014: Research associate, Dept. of Chemistry, University of Cambridge
- 2011 – 2013: Postdoctoral researcher with Prof. David Klenerman, Dept. of Chemistry, University of Cambridge
- 2010: PhD in Physics, Chalmers (supervisor Prof. Fredrik Höök)
- 2006: MSc in Engineering Physics, Lund University
- 2021 - present: Science Faculty board member (Lärarförslagsnämnden).
- 2019 - present: Deputy head of the Physical Chemistry Division.
- 2014 - present: Board Member of the research graduate school ADMIRE at LU.