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Tommy Dam: Public defence

Seminarium

From: 2022-12-14 13:00 to 16:00
Place: KC:A
Contact: peter [dot] jonsson [at] fkem1 [dot] lu [dot] se
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Tommy Dam, PhD student by Physical Chemistry, Lund University will defend his doctoral thesis.

Place: Lecturehall KC:A

Opponent: Professor Anton van der Merwe, University of Oxford, United Kingdom.

Titel: The influence of adhesion molecules on binding and protein organization in cell contacts

Abstract

Interactions between immune cells such as T cells and antigen-presenting cells (APCs) are integral for mounting an adaptive immune response. The interaction between the T cell receptor (TCR) and the antigen-presenting major histocompatibility complex (pMHC) on a contacting T cell and APC, is widely accepted to be the key interaction. If the interaction is favourable, then T cell activation occurs. A large pool of research has been aimed at characterizing this interaction by measuring the binding kinetics and relating it to the T cell response. A simplified model membrane system called a supported lipid bilayer (SLB) is often used to mimic the membrane of the APC.