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Benjamin Boyd: Physical Chemistry seminar

Seminarium

From: 2021-06-07 10:00 to 11:00
Place: Zoom
Contact: peter [dot] jonsson [at] fkem1 [dot] lu [dot] se
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Physical Chemistry seminar: Professor Benjamin Boyd, Monash University, Australia 

Title: Milk as a colloidal drug delivery system

Abstract: While biological drugs are becoming more prevalent, the majority of drug molecules coming out of discovery programs are still small molecule lipophilic compounds. Strategies to enhance the bioavailability of these drugs include their incorporation into lipid based formulations. The industry approach to lipid based formulations is to maximise drug solubility and dispersibility of the formulation – the use of surfactants and cosolvents is ubiquitous but carries a high risk of drug precipitation and high cost precluding the use of such formulations in low economy settings. We have been studying the colloidal aspects of milk and related materials during digestion [1] and have progressed to understanding the potential of milk and infant formula as possible low cost drug delivery systems where an appreciation of the impact of digestion is critical [2]. We have shown that for some drugs milk provides a dramatic enhancement in drug dissolution during digestion which has correlated with drug absorption in clinical trials when compared to surfactant based formulations. This finding has opened new low cost formulation options for treatment of diseases such as malaria [3] and cryptosporidiosis [4] in a format suitable for the most vulnerable paediatric patients.

 

[1] Salentinig, S.; Phan, S.; Khan, J.; Hawley, A.; Boyd, B. J., Formation of Highly Organized Nanostructures during the Digestion of Milk. ACS Nano 2013, 7 (12), 10904-10911.

[2] Boyd, B. J.; Salim, M.; Clulow, A. J.; Ramirez, G.; Pham, A. C.; Hawley, A., The impact of digestion is essential to the understanding of milk as a drug delivery system for poorly water soluble drugs. Journal of controlled release : official journal of the Controlled Release Society 2018, 292, 13-17.

[3] Salim, M.; Khan, J.; Ramirez, G.; Clulow, A. J.; Hawley, A.; Ramachandruni, H.; Boyd, B. J., Interactions of Artefenomel (OZ439) with Milk during Digestion: Insights into Digestion-Driven Solubilization and Polymorphic Transformations. Mol Pharm 2018, 15 (8), 3535-3544.

[4] Salim, M.; Ramirez, G.; Clulow, A. J.; Zhang, Y.; Ristroph, K. D.; Feng, J.; McManus, S. A.; Hawley, A.; Prud'homme, R. K.; Boyd, B. J., Solid-State Behavior and Solubilization of Flash Nanoprecipitated Clofazimine Particles during the Dispersion and Digestion of Milk-Based Formulations. Mol Pharm 2019, 16 (6), 2755-2765.

TOPIC: Benjamin Boy: Physical Chemistry seminar
WHEN: Jun 7, 2021 10:00 AM Stockholm
WHERE: LU Zoom meeting: https://lu-se.zoom.us/j/65211873274