The major goal of this project is to provide fundamental new knowledge on a relatively unexplored phenomenon: the co-assembly of amyloid-forming peptides and proteins with lipid molecules. The results will have implications for peptide aggregation in complex environments and will forward our understanding of biologically functional peptide assemblies, peptide-based materials as well as aberrant peptide aggregation. The specific aims are to understand: (i) thermodynamic driving forces and equilibria, (ii) molecular aggregation pathways and kinetics, and (iii) factors that determine the composition, structure and physical-chemical properties of co-aggregates. The project will contribute to a deepened general understanding of peptide-lipid interactions and how these govern co-assembly into lipid-rich and protein-rich aggregates. 

People:  Peter Jönsson, Ulf Olsson, Sara Snogerup Linse, Emma Sparr,Daniel Topgaard. 

Contact person: Emma Sparr