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Physical Chemistry

Lund University

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Publications Emma Sparr

88. Andersson, J.M., Pham, Q.D., Mateos, H., Eriksson, S., Harryson, P., Sparr, E.
The plant dehydrin Lti30 stabilizes lipid lamellar structures in varying hydration conditions

J. Lip Research (2020) In press

 

87. Gaspar, R. Lund, M., Sparr, E., Linse, S.
Anamalous salt dependence reveals an interplay of attractive and repulsive electrostatic interactions in a-synuclein fibril formation
QRB-D (2020) In press

 

86. Stenqvist B., Sparr E.

Tortuosity in the Brick and Mortar Model based on Chemical Conductiton

Chem Eng Sci (2020) In press

 

85. Pham Q.D, Carlström G., Lafon O., Sparr E., Topgaard, D.

Quantification of the amount of mobile components in intact stratum corneum with natural-abundance 13C solid-state NMR

Phys Chem Chem Phys (2020) In press

 

84. Mujumdar, E.H., Grey, C. Sparr, E.S.

Self-Assembly in Ganglioside-Phospholipid Systems: The Co-Existence of Vesicles, Micelles, and Discs

Int. J. Molecular Sci (2020) 21,56

 

83.C. Galvagnion, D. Topgaard, K. Makasewicz, A.K. Buell, S. Linse, E. Sparr, C. Dobson
Lipid dynamics and phase transition within a-synuclein amyloid fibrils. 

J. Phys. Chem. Lett (2019) 10, 7872

 

82. A. Wolde-Kidan, Q. D. Pham, A. Schlaich, P. Loche, E: Sparr, R.R. Netz, E. Schneck

Influence of Polar Co-Solutes and Salt on the Hydration of Lipid Membranes

Phys Chem Chem Phys (2019) 21, 16989

 

81.E. Sparr, S. Linse
Lipid-protein interactions in amyloid formation. 

Biochim Biophys Acta - Proteins and Proteomics (2019) 1867, 455

 

80. M. Wang, A.M. Mihut, E. Rieloff, A.P. Dabkowska, L.K. Månsson, J.N. Immink, E. Sparr, J. Crassous. 

Assembling Responsing Microgels at Responsive Lipid Membrane

PNAS (2019) 116, 5442


79. J. Pallbo, E. Sparr, U. Olsson

Aggregation behavior of the amyloid model peptide NACore

Q Rev Biophys-Discovery (2019) 52, e4, 1-10

 

78. J. Andersson, K. Roger, M. Larsson, E. Sparr. 

The impact of non-equilibrium conditions in lung surfactant: structure and composition gradients in multilamellar films. 

ACS Central Science (2018) 4, 1315

 

77. R. Gaspar, J. Pallbo, U. Weininger, S. Linse, E. Sparr.

Ganglioside lipids accelerate ?-synuclein amyloid formation

Biochim Biophys Acta - Proteins and Proteomics (2018) 1866,1062

 

76. Q.D. Pham, A. Wolde-Kidan, A. Gupta, E. Schneck, R. Netz, E. Sparr. 

Effects of Urea and TMAO on Lipid Self-Assembly under Osmotic Stress Conditions

J. Phys Chem B (2018) 1255, 6471 (selected for journal cover)

 

75. Q. D. Pham, E. H. Mojumdar, G.S. Gooris, J.A. Bouwstra, E. Sparr, D. Topgaard.

Solid and Fluid Hydrocarbon chains within the same molecule in stratum corneum lamellar lipid structure.

Q. Rev Biophys - Discovery (2018) 51, e7. 

 

74. J. Habchi, S. Chia, C. Galvagnion, T. C. T. Michaels, M. Bellaiche, F. S. Ruggeri, M. Sanguanini, I. Idini, J. R. Kumita, E. Sparr, S. Linse, C. M. Dobson, T. P. J. Knowles, M. Vendruscolo. 

Cholesterol catalyses Ab42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. 

Nature Chemistry (2018) 10, 673

 

 73. K. Roger, E. Sparr, H. Wennerström. 

Evaporation, diffusion and self-assembly at drying interfaces. 

PCCP (2018) 20, 10430

 

72. G. Tesei, E. Hellstrand, K. Sanagavarapu, S. Linse, E. Sparr, R. Vacha, M. Lund. 

Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces. 

Langmuir (2018) 34, 1266

 

71.E.H. Mujumdar, Q.D. Pham, D. Topgaard, E. Sparr. 

Skin Hydration: Interplay between molecular dynamics, structure and water uptake in the stratum corneum. 

Sci Reports (2017) 7, 15712

 

70. J. M. Andersson, C. Grey, M. Larsson, T.M. Ferreira, E. Sparr. 

Effect of cholesterol on the molecular structure and transitions in a clinical-grade lung surfactant extract. 

PNAS (2017) 114, E3592-E3601

 

69. Q.D. Pham, D. Topgaard, E. Sparr. 

Tracking solvents in the skin- Molecular mobility of solvents, lipids and protein in intact stratum corneum. 

PNAS (2017) 114, E112-E121

 

68. R. Gaspar, G. Meisl, A. K. Buell, L. Young, C.F. Kaminski, T.P.J. Knowles, E. Sparr, S. Linse. 

Secondary nucleation of monomers on fibril surface dominates a-synuclein aggregation and provides autocatalytic amyloid amplification. 

Quart. Rev. Biophysics (2016) 50, e6

 

67. A.P. Dabkowska, A. Michanek, L. Jaeger, A. Chworos, T. Nylander, E. Sparr. 

Supported fluid bilayers as scaffolds to direct the assembly of RNA nanostructures, 

in "RNA nanostructures". Eds. Bruce Shapiro and Eckart Bindewald. Methods in Molecular Biology, Springer lab protocol series (2016) 

 

66. K. Roger, M. Liebi, J. Heimdal, Q.D. Pham, E. Sparr. 

Controlling evaporation through self-assembly. 

PNAS (2016) 113, 10275

 

65. S. Björklund, D.Q. Pham, L.B. Jensen, N.O. Knudsen, L.D. Nielsen, K. Ekelund, T. Ruzgas, J. Engblom, E. Sparr. 

The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. 

J Colloid Interface  Sci (2016) 479:207-2

 

64. C. Galvagnion , J.W.P. Brown  , M.M. Ouberai, P. Flagmeier , M. Vendruscolo, A.K. Buell, E. Sparr,  C.M. Dobson. 

The chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of alpha-synuclein. 

PNAS (2016) 113, 7065-70

 

63. Q.D. Pham, S. Björklund, J. Engblom, D. Topgaard, E. Sparr. 

Chemical penetration enhancers in stratum corneum — Relation between molecular effects and barrier function. 

J Controlled Release (2016) 232, 175-187

 

62. A. Runnsjö, A. Dabkowska, E. Sparr, V. Kocherbitov, T. Arnebrant, J. J. Engblom. 

Diffusion through Pig Gastric Mucin: Effect of Relative Humidity. 

Plos One (2016) DOI:10.1371/journal.pone.0157596

 

61. Q.D. Pham, D. Topgaard, E. Sparr. 

Cyclic and linear monoterpenes in phospholipid membranes; Phase behaviour, bilayer structure and molecular dynamics. 

Langmuir (2015) 31, 11067-77

 

60. A. Dabkowska, A. Michanel, L. Jaeger, M. Rabe, F. Höök, T. Nylander, E. Sparr.

Assembly of RNA nanostructures on supported lipid bilayers. 

Nanoscale (2015) 7, 583–596

 

59. M. Grey, C. Dunning, R. Gaspar, C. Grey, P. Brundin, E. Sparr, S. Linse.

Acceleration of a-synuclein aggregation by exosomes. 

J Biol Chem (2015) 290, 2969–2982

 

58.T. Mokhtari, Q.D. Pham, C. Hirst, B.M.D. O'Driscoll, T. Nylander, K.J. Edler, E. Sparr. 

Controlling interfacial film formation in polymer-surfactant systems by changing the vapor phase. 

Langmuir (2014) 30, 9991

 

57. S. Björklund, J.M. Andersson, Q.D. Pham, A. Nowacka, D. Topgaard, E. Sparr. 

Stratum corneum molecular mobility in the presence of natural moisturizers. 

Soft Matter (2014) 10, 4535-4546

 

56. A.K. Buell, C. Galvagnion, R. Gaspar, E. Sparr, M. Vendruscolo, T.P.J. Knowles S. Linse, C.M. Dobson 

Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation.
Proc Natl Acad Sci USA (2014) 111. 7671-7677

 

55. M. Eeman, G. Olofsson, E. Sparr, M.N. Nasir, T. Nylander, M. Deleu. 

Interaction of fengycin with stratum corneum mimicking model membranes: a calorimetry study. 

Coll Surf B: Biointerfaces (2014) 121,27

 

54. E. Hellstrand, A. Nowacka, D. Topgaard, S. Linse, E. Sparr.

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils

PLoS ONE (2013) e61889

 

53. E. Hellstrand, M. Grey, M-L- Ainalem, J. Ankner, T. Forsyth, G. Fragneto, M. Haetlein, M.T. Dauvergne, H. Nilsson, P. Brundin, S. Linse, T. Nylander, E. Sparr. 

Adsorption of a-synuclein to supported lipid bilayers - positioning and role of electrostatics

ACS Chem Neurosci (2013) 4, 1339-1351

 

52. G. Olofsson, E. Sparr. 

Ionization constants pKa of cardiolipin

PLoS ONE (2013) e73040

51. S. Björklund, J. Engblom, K. Thuresson, E. Sparr. 

Glycerol and urea can be used to increase skin permeability in reduced hydration conditions

Eur J Pharm Sci (2013) 50, 638-645

50. S. Björklund, A. Nowacka, J.A. Bouwstra, E. Sparr, D. Topgaard. 

Characterization of stratum corneum molecular dynamics by natural-abundance 13C solid-state NMR

PLOS One (2013). 8, e61889

49.  E. Sparr, D. Millecamp, M .Isoir, V. Burnier, Å. Larsson, B. Cabane. 

Controlling the hydration of the skin though the application of occluding barrier creams.

JRS Interface (2013) 10, 20120788

48.  S. Björklund, , T. Ruzgas, A. Nowacka, I. Dahi, D. Topggard, E. Sparr, J. Engblom 

Skin Membrane Electrical Impedance Properties under the Influence of a Varying Water Gradient. 

Biophys J (2013) 104, 2639-2650

47.  A. Michanek, T. Nylander, E. Sparr. 

ssRNA base pairing at a bilayer interface can be controlled by c  acyl chain order

Soft Matter (2012) 8, 10428

46. A. Michanek, M. Yanez, H. Wacklin, A. Hughes, T. Nylander, E. Sparr, 

RNA and DNA Association to Zwitterionic and Charged Monolayers at the Air-Liquid Interface

Langmuir (2012) 28, 9692

45.  C. Åberg, E. Sparr, H. Wennerström, 

Lipid Phase Behaviour under Steady-State Conditions (2012) 

Faraday Discussions. I61, 151-161

44.  A. Nowacka, S. Douezan, L. Wadsö, D. Topgaard, and E. Sparr 

Small polar molecules like glycerol and urea can preserve the fluidity of lipid bilayers under dry conditions

Soft Matter (2012) 8, 1482

43.  P. Falkman, C. Åberg, A. Clemens, E. Sparr. 

Lyotropic lipid phases confined in cylindrical pores - Structure and Permeability

J. Phys. Chem B (2011) 115, 14450–14461

42. M. Grey, S. Linse, H. Nilsson, P. Brundin, E. Sparr. 

Membrane Interaction of a-Synuclein in Different Aggregation States

Journal of Parkinson’s Disease 1 (2011) 359–371

 

41. E. Sparr, H. Wennerström.
Interlamellar forces and the thermodynamic characterization of lamellar phospholipid systems

Curr Op Coll Interf Sci (2011) 16, 561–567

 

40. S. Björklund, J. Engblom, K. Thuresson, E. Sparr. 

A water gradient can be used to regulate drug transport across skin

J. Control Release (2010) 143, 191-200

 

39. A Michanek, N. Kristen, F. Höök, T. Nylander, E. Sparr. 

RNA and DNA interactions with zwitterionic and charged lipid membranes — A DSC and QCM-D study

Biophys Biochim Acta – Biomembranes (2010) 1798 829-838

 

38. E. Hellstrand, E. Sparr, S. Linse. 

Retardation of A beta fibril formation by phospholipid vesicles depends on membrane phase behaviour

Biophys. J. (2010) 98, 1-9

 

37. C. Åberg, E. Sparr, M. Larsson, H. Wennerström. 

A theoretical study of diffusional transport over the alveolar surfactant layer. 

Journal of the Royal Society Interface (2010) 7, 1403-1410

 

36. M.L. Ainalem, N. Kristen, K. Edler, F. Höök, E. Sparr, T. Nylander. 

DNA binding to zwitterionic model membranes

Langmuir (2010) 26, 4965-4976

 

35. F.O. Costa-Balogh, E. Sparr, J.J.S. Sousa, A.A.C.C. Pais. 

Drug release from lipid liquid crystalline phases: relation with phase behaviour. 

Drug Dev Ind Pharm (2010) 36, 470-481

 

34. E. Sparr, C. Åberg, P. Nilsson, H. Wennerström. 

Diffusional transport in responding lipid membranes

Soft Matter, (2009) 5, 3225-3233

 

33. C. Åberg, E, Sparr, K. Edler, H. Wennerström. 

Non-Equilibrium Phase Transformations at the Air-Liquid Interface

Langmuir (2009) 25, 12177–12184

 

32. F.O. Costa-Balogh, E. Sparr, J.J.S. Sousa, A.A.C.C Pais. 

Drug release and skin permeation from lipid liquid crystalline phases

Progr Coll Polym Sci (2008) 135, 119-129

 

31. C. Åberg, H. Wennerström, E. Sparr. 

Transport Processes in Responding Lipid Membranes: A Possible Mechanism for the pH Gradient in the Stratum Corneum

Langmuir (2008) 24, 8061-8070

 

30. C. Åberg, C. Pairin, F. Costa-Balogh, E. Sparr. 

Responding Double-Porous Lipid Membranes.
Biochim. Biophys. Acta – Biomembranes (2007) 1778, 549-558

 

29. C.L. Silva, D. Topgaard, V. Kocherbitov, J.J.S. Sousa, A.A.C.C. Pais, E. Sparr. 

Stratum corneum hydration: phase transformations and mobility in stratum corneum, extracted lipids and isolated corneocytes.  

Biochim. Biophys. Acta – Biomembranes (2007) 1768, 2647-2659

 

28. F. Costa-Balogh, H. Wennerström, L. Wadsö, E. Sparr. 

How small polar molecules protect membranes against osmotic stress: The urea–water-phospholipid system. 

J. Phys. Chem. B (2006) 110, 23845-23852

 

27. B. de Kruijff, J.A. Killian, D.N. Ganchev, H.A.Rinia, E. Sparr. 

Striated domain self-organizing ordered assemblies of transmembrane a-helical peptides and lipids in bilayers. 

Chem. Biol. (2005) 387, 235–241

 

26. E. Sparr, W.A. Ash, P.V.Nazarov, D.T.S. Rijkers, M.A. Hemminga, D.P. Tieleman, J.A. Killian. 

Self-association of transmembrane a-helices in model membranes: importance of helix orientation and role of hydrophobic mismatch. 

J. Biol. Chem . (2005) 280, 39324-39331

 

25. F. Costa-Balogh, C. Åberg, J.J. Sousa, E. Sparr. 

Drug transport in responding lipid membranes can be regulated by an external osmotic gradient. 

Langmuir, (2005) 21, 10307-10310

 

24. E. Sparr, D. Ganchev, A. Ridder, D. Rijkers, L. Kroon-Batenburg, V. Chupin, J.A. Killian, B. de Kruijff. 

Molecular organization of striated domains formed by transmembrane a-helical peptides in dipalmitoylphosphatidylcholine bilayers. 

Biochemistry (2005) 44, 2-10

 

23. E. Sparr, M.F.M. Engel, D.V. Sakharov, M. Sprong, J. Jacobs,  B. de Kruijff, J.W.M. Höppener, J. A. Killian. 

Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. 

FEBS Lett (2004) 577, 117–120

 

22. E. Sparr, P. Wadsten, V. Kocherbitov, S. Engström. 

The effect of bacteriorhodopsin, detergent and hydration on the cubic-to-lamellar phase transition in the monoolein-distearoyl phosphatidyl glycerol-water system. 

Biochim. Biophys Acta (2004) 1665, 156-165

 

21. N. Merclin, J. Bender, E. Sparr, H. Ehrsson, R. Guy, S. Engström. 

Transdermal delivery from a lipid sponge phase –iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester. 

J. Contr. Rel. (2004) 100, 191-198

 

20. A. Thapper, E. Sparr, B.F.G. Johnson, J. Lewis, P.R. Raithby, E. Norlander. 

Reversible p-coordination of triallylphosphine in a trinuclear ruthenium carbonyl cluster. 

Inorg. Chem. Comm. (2004) 7, 443-446

 

19. H. Wennerström, E. Sparr. 

The Thermodynamics of Membrane Lipid Hydration.  

Pure Appl. Chem. (2003) 75, 905-912

 

18. E. Sparr, L. Hallin, N. Markova, H. Wennerström. 

Cholesterol-Phospholipid Bilayers under Osmotic Stress.  

Biophys. J. (2002) 83, 2115-2125

 

17. H. Gillgren, A. Stenstam, E. Sparr, S. Ulvenlund. 

Morphology and Molecular Conformation in Thin Films of Poly-g-methyl-L-glutamate at the Air-Water Interface.  

Langmuir (2002) 18, 462-469

 

16. E. Sparr, H. Wennerström. 

Responding Binary Phospholipid Membranes - Interplay between Hydration and Permeability. 

Biophys. J. (2001) 81, 1014-1028

 

15. E. Sparr, L. Eriksson, J.A. Bouwstra , K. Ekelund. 

An AFM Study on Lipid Monolayers: III. Phase Behaviour of Ceramides, Cholesterol and Fatty Acids. 

Langmuir (2001) 17, 164-172

 

14. N. Markova, E. Sparr, L. Wadsö. 

Applications of the Double Twin Isothermal Microcalorimeter – Phase Transformations and Clay Swelling.  

Thermochim. Acta (2001) 374, 93-104

 

13. S. Ulvenlund, H. Gillgren, A. Stenstam, P. Bäckman, E. Sparr 

Hydrophobic homopolymers of native a-L-amino acids at the air-water interface: A study by circular dichronism spectroscopy, atomic force microscopy, and surface balance experiments.  

J. Colloid Interface Sci. (2001) 242, 346-353

 

12. E. Sparr, H. Wennerström. 

Diffusion through a Responding Lamellar Liquid Crystal. 

A Model of Molecular Transport across Stratum Corneum. 

Colloids and Surfaces, B: Biointerfaces (2000) 19, 103-116

 

11. N. Markova, E. Sparr, L. Wadsö, H. Wennerström. 

A Calorimetric Study of Phospholipid Hydration. Simultaneous Monitoring of Enthalpy and Free Energy. 

J. Phys. Chem. B (2000) 104, 8053-8060

 

10.    K. Ekelund, L. Eriksson, E. Sparr. 

Rectangular Solid Domains in Ceramide-Cholesterol Monolayers- 2D Crystals. 

Biochim. Biophys. Acta (2000) 1464, 1-6

 

9.   S. Engström, K. Ekelund, J. Engblom, L. Eriksson, E. Sparr, H. Wennerström. 

The Skin Barrier from a Lipid Perspective.  

Acta Derm. Venerol. (2000) 208, 31-35

 

8.   E.C. Constable, C.E. Housecroft, M. Neuburger, D. Philips, P.R. Raithby, E. Schofield, E. Sparr, D.A. Tocher, M. Zehnder, Y. Zimmermann. 

Development of supramolecular structure through alkylation of pendant pyridyl functionality. 

J. Chem. Soc. Dalton Trans. (2000) 13, 2219-2228

 

7.    L.P. Clarke, J.E. Davies, P.R. Raithby, M.A. Rennie, G.P. Shields, E. Sparr. 

Reaction of [Os3H2(CO)(10)] with the diyne Me3SiC2C2SiMe3 and the reactivity of the products towards [Co-2(CO)(8)]: the X-ray structures of [Os-3(m-H)(CO)(10){ m-z (1)- z (2)-HC2(SiMe3)C-2(SiMe3)}], [Os-3(m-CO)(CO)(9){ m (3)-z(2)-Me3SiC2C2SiMe3}] and [Os-3(m-H)(CO)(9){ m (3)- z (1): z (2)-; m-z(2)-Me3SiC2C2[Co-2(CO)(6)]}].  

J. Organometallic Chem. (2000) 609, 169-176

 

6.    E. Sparr, K. Ekelund, J. Engblom, S. Engström, H. Wennerström. 

An AFM Study on Lipid Monolayers: II. The Effect of Cholesterol on Fatty Acids. 

Langmuir (1999) 15, 6950-6955

 

5.    K. Ekelund, E. Sparr, J. Engblom, H. Wennerström, S. Engström. An AFM Study on Lipid Monolayers: I. Pressure-Induced Phase Behaviour of Plain and Mixed Fatty Acids.
Langmuir (1999) 15, 6946-6949

 

4.    F.H. Allen, C.A. Baalham, J.P.M. Lommerse, P.R. Raithby, E. Sparr. 

Hydrogen-bond acceptor properties of nitro-O atoms: a combined crystallographic database and ab initio molecular orbital study.  

Acta Cryst. (1997) B53, 1017-1024

 

BOOK CHAPTERS

3. E Sparr. 

Sju stora beslut och tre små tips. Chapter in antholgy “Vägar till vetenskapen”,  Editor K. Nordlund. Santérus förlag (2013)

 

2. E. Sparr. 

Osynlig rörelse. Chapter in interdisciplinary antholgy “TEMPO”, Editors H. Sandberg, M. Cronqvist. Makadam förlag (2008)

 

1. E. Sparr, S. Engström. 

Lipid Phase Behaviour – Basis for an Understanding of Membrane Structure and Function. Book chapter in ‘Hair; Nail and Skin: Structure and function’ (Eds. B. Forslind, M. Lindberg, Marcel Dekker). 2004