Publications Emma Sparr
88. Andersson, J.M., Pham, Q.D., Mateos, H., Eriksson, S., Harryson, P., Sparr, E.
The plant dehydrin Lti30 stabilizes lipid lamellar structures in varying hydration conditions
J. Lip Research (2020) In press
87. Gaspar, R. Lund, M., Sparr, E., Linse, S.
Anamalous salt dependence reveals an interplay of attractive and repulsive electrostatic interactions in a-synuclein fibril formation
QRB-D (2020) In press
86. Stenqvist B., Sparr E.
Tortuosity in the Brick and Mortar Model based on Chemical Conductiton
Chem Eng Sci (2020) In press
85. Pham Q.D, Carlström G., Lafon O., Sparr E., Topgaard, D.
Quantification of the amount of mobile components in intact stratum corneum with natural-abundance 13C solid-state NMR
Phys Chem Chem Phys (2020) In press
84. Mujumdar, E.H., Grey, C. Sparr, E.S.
Self-Assembly in Ganglioside-Phospholipid Systems: The Co-Existence of Vesicles, Micelles, and Discs
Int. J. Molecular Sci (2020) 21,56
83.C. Galvagnion, D. Topgaard, K. Makasewicz, A.K. Buell, S. Linse, E. Sparr, C. Dobson
Lipid dynamics and phase transition within a-synuclein amyloid fibrils.
J. Phys. Chem. Lett (2019) 10, 7872
82. A. Wolde-Kidan, Q. D. Pham, A. Schlaich, P. Loche, E: Sparr, R.R. Netz, E. Schneck
Influence of Polar Co-Solutes and Salt on the Hydration of Lipid Membranes
Phys Chem Chem Phys (2019) 21, 16989
81.E. Sparr, S. Linse
Lipid-protein interactions in amyloid formation.
Biochim Biophys Acta - Proteins and Proteomics (2019) 1867, 455
80. M. Wang, A.M. Mihut, E. Rieloff, A.P. Dabkowska, L.K. Månsson, J.N. Immink, E. Sparr, J. Crassous.
Assembling Responsing Microgels at Responsive Lipid Membrane
PNAS (2019) 116, 5442
79. J. Pallbo, E. Sparr, U. Olsson
Aggregation behavior of the amyloid model peptide NACore
Q Rev Biophys-Discovery (2019) 52, e4, 1-10
78. J. Andersson, K. Roger, M. Larsson, E. Sparr.
The impact of non-equilibrium conditions in lung surfactant: structure and composition gradients in multilamellar films.
ACS Central Science (2018) 4, 1315
77. R. Gaspar, J. Pallbo, U. Weininger, S. Linse, E. Sparr.
Ganglioside lipids accelerate ?-synuclein amyloid formation
Biochim Biophys Acta - Proteins and Proteomics (2018) 1866,1062
76. Q.D. Pham, A. Wolde-Kidan, A. Gupta, E. Schneck, R. Netz, E. Sparr.
Effects of Urea and TMAO on Lipid Self-Assembly under Osmotic Stress Conditions
J. Phys Chem B (2018) 1255, 6471 (selected for journal cover)
75. Q. D. Pham, E. H. Mojumdar, G.S. Gooris, J.A. Bouwstra, E. Sparr, D. Topgaard.
Solid and Fluid Hydrocarbon chains within the same molecule in stratum corneum lamellar lipid structure.
Q. Rev Biophys - Discovery (2018) 51, e7.
74. J. Habchi, S. Chia, C. Galvagnion, T. C. T. Michaels, M. Bellaiche, F. S. Ruggeri, M. Sanguanini, I. Idini, J. R. Kumita, E. Sparr, S. Linse, C. M. Dobson, T. P. J. Knowles, M. Vendruscolo.
Cholesterol catalyses Ab42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.
Nature Chemistry (2018) 10, 673
73. K. Roger, E. Sparr, H. Wennerström.
Evaporation, diffusion and self-assembly at drying interfaces.
PCCP (2018) 20, 10430
72. G. Tesei, E. Hellstrand, K. Sanagavarapu, S. Linse, E. Sparr, R. Vacha, M. Lund.
Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces.
Langmuir (2018) 34, 1266
71.E.H. Mujumdar, Q.D. Pham, D. Topgaard, E. Sparr.
Skin Hydration: Interplay between molecular dynamics, structure and water uptake in the stratum corneum.
Sci Reports (2017) 7, 15712
70. J. M. Andersson, C. Grey, M. Larsson, T.M. Ferreira, E. Sparr.
Effect of cholesterol on the molecular structure and transitions in a clinical-grade lung surfactant extract.
PNAS (2017) 114, E3592-E3601
69. Q.D. Pham, D. Topgaard, E. Sparr.
Tracking solvents in the skin- Molecular mobility of solvents, lipids and protein in intact stratum corneum.
PNAS (2017) 114, E112-E121
68. R. Gaspar, G. Meisl, A. K. Buell, L. Young, C.F. Kaminski, T.P.J. Knowles, E. Sparr, S. Linse.
Secondary nucleation of monomers on fibril surface dominates a-synuclein aggregation and provides autocatalytic amyloid amplification.
Quart. Rev. Biophysics (2016) 50, e6
67. A.P. Dabkowska, A. Michanek, L. Jaeger, A. Chworos, T. Nylander, E. Sparr.
Supported fluid bilayers as scaffolds to direct the assembly of RNA nanostructures,
in "RNA nanostructures". Eds. Bruce Shapiro and Eckart Bindewald. Methods in Molecular Biology, Springer lab protocol series (2016)
66. K. Roger, M. Liebi, J. Heimdal, Q.D. Pham, E. Sparr.
Controlling evaporation through self-assembly.
PNAS (2016) 113, 10275
65. S. Björklund, D.Q. Pham, L.B. Jensen, N.O. Knudsen, L.D. Nielsen, K. Ekelund, T. Ruzgas, J. Engblom, E. Sparr.
The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier.
J Colloid Interface Sci (2016) 479:207-2
64. C. Galvagnion , J.W.P. Brown , M.M. Ouberai, P. Flagmeier , M. Vendruscolo, A.K. Buell, E. Sparr, C.M. Dobson.
The chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of alpha-synuclein.
PNAS (2016) 113, 7065-70
63. Q.D. Pham, S. Björklund, J. Engblom, D. Topgaard, E. Sparr.
Chemical penetration enhancers in stratum corneum — Relation between molecular effects and barrier function.
J Controlled Release (2016) 232, 175-187
62. A. Runnsjö, A. Dabkowska, E. Sparr, V. Kocherbitov, T. Arnebrant, J. J. Engblom.
Diffusion through Pig Gastric Mucin: Effect of Relative Humidity.
Plos One (2016) DOI:10.1371/journal.pone.0157596
61. Q.D. Pham, D. Topgaard, E. Sparr.
Cyclic and linear monoterpenes in phospholipid membranes; Phase behaviour, bilayer structure and molecular dynamics.
Langmuir (2015) 31, 11067-77
60. A. Dabkowska, A. Michanel, L. Jaeger, M. Rabe, F. Höök, T. Nylander, E. Sparr.
Assembly of RNA nanostructures on supported lipid bilayers.
Nanoscale (2015) 7, 583–596
59. M. Grey, C. Dunning, R. Gaspar, C. Grey, P. Brundin, E. Sparr, S. Linse.
Acceleration of a-synuclein aggregation by exosomes.
J Biol Chem (2015) 290, 2969–2982
58.T. Mokhtari, Q.D. Pham, C. Hirst, B.M.D. O'Driscoll, T. Nylander, K.J. Edler, E. Sparr.
Controlling interfacial film formation in polymer-surfactant systems by changing the vapor phase.
Langmuir (2014) 30, 9991
57. S. Björklund, J.M. Andersson, Q.D. Pham, A. Nowacka, D. Topgaard, E. Sparr.
Stratum corneum molecular mobility in the presence of natural moisturizers.
Soft Matter (2014) 10, 4535-4546
56. A.K. Buell, C. Galvagnion, R. Gaspar, E. Sparr, M. Vendruscolo, T.P.J. Knowles S. Linse, C.M. Dobson
Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation.
Proc Natl Acad Sci USA (2014) 111. 7671-7677
55. M. Eeman, G. Olofsson, E. Sparr, M.N. Nasir, T. Nylander, M. Deleu.
Interaction of fengycin with stratum corneum mimicking model membranes: a calorimetry study.
Coll Surf B: Biointerfaces (2014) 121,27
54. E. Hellstrand, A. Nowacka, D. Topgaard, S. Linse, E. Sparr.
Membrane Lipid Co-Aggregation with α-Synuclein Fibrils.
PLoS ONE (2013) e61889
53. E. Hellstrand, M. Grey, M-L- Ainalem, J. Ankner, T. Forsyth, G. Fragneto, M. Haetlein, M.T. Dauvergne, H. Nilsson, P. Brundin, S. Linse, T. Nylander, E. Sparr.
Adsorption of a-synuclein to supported lipid bilayers - positioning and role of electrostatics.
ACS Chem Neurosci (2013) 4, 1339-1351
52. G. Olofsson, E. Sparr.
Ionization constants pKa of cardiolipin.
PLoS ONE (2013) e73040
51. S. Björklund, J. Engblom, K. Thuresson, E. Sparr.
Glycerol and urea can be used to increase skin permeability in reduced hydration conditions.
Eur J Pharm Sci (2013) 50, 638-645
50. S. Björklund, A. Nowacka, J.A. Bouwstra, E. Sparr, D. Topgaard.
Characterization of stratum corneum molecular dynamics by natural-abundance 13C solid-state NMR.
PLOS One (2013). 8, e61889
49. E. Sparr, D. Millecamp, M .Isoir, V. Burnier, Å. Larsson, B. Cabane.
Controlling the hydration of the skin though the application of occluding barrier creams.
JRS Interface (2013) 10, 20120788
48. S. Björklund, , T. Ruzgas, A. Nowacka, I. Dahi, D. Topggard, E. Sparr, J. Engblom
Skin Membrane Electrical Impedance Properties under the Influence of a Varying Water Gradient.
Biophys J (2013) 104, 2639-2650
47. A. Michanek, T. Nylander, E. Sparr.
ssRNA base pairing at a bilayer interface can be controlled by c acyl chain order.
Soft Matter (2012) 8, 10428
46. A. Michanek, M. Yanez, H. Wacklin, A. Hughes, T. Nylander, E. Sparr,
RNA and DNA Association to Zwitterionic and Charged Monolayers at the Air-Liquid Interface.
Langmuir (2012) 28, 9692
45. C. Åberg, E. Sparr, H. Wennerström,
Lipid Phase Behaviour under Steady-State Conditions (2012)
Faraday Discussions. I61, 151-161
44. A. Nowacka, S. Douezan, L. Wadsö, D. Topgaard, and E. Sparr
Soft Matter (2012) 8, 1482
43. P. Falkman, C. Åberg, A. Clemens, E. Sparr.
Lyotropic lipid phases confined in cylindrical pores - Structure and Permeability.
J. Phys. Chem B (2011) 115, 14450–14461
42. M. Grey, S. Linse, H. Nilsson, P. Brundin, E. Sparr.
Membrane Interaction of a-Synuclein in Different Aggregation States.
Journal of Parkinson’s Disease 1 (2011) 359–371
41. E. Sparr, H. Wennerström.
Interlamellar forces and the thermodynamic characterization of lamellar phospholipid systems.
Curr Op Coll Interf Sci (2011) 16, 561–567
40. S. Björklund, J. Engblom, K. Thuresson, E. Sparr.
A water gradient can be used to regulate drug transport across skin.
J. Control Release (2010) 143, 191-200
39. A Michanek, N. Kristen, F. Höök, T. Nylander, E. Sparr.
RNA and DNA interactions with zwitterionic and charged lipid membranes — A DSC and QCM-D study.
Biophys Biochim Acta – Biomembranes (2010) 1798 829-838
38. E. Hellstrand, E. Sparr, S. Linse.
Retardation of A beta fibril formation by phospholipid vesicles depends on membrane phase behaviour.
Biophys. J. (2010) 98, 1-9
37. C. Åberg, E. Sparr, M. Larsson, H. Wennerström.
A theoretical study of diffusional transport over the alveolar surfactant layer.
Journal of the Royal Society Interface (2010) 7, 1403-1410
36. M.L. Ainalem, N. Kristen, K. Edler, F. Höök, E. Sparr, T. Nylander.
DNA binding to zwitterionic model membranes.
Langmuir (2010) 26, 4965-4976
35. F.O. Costa-Balogh, E. Sparr, J.J.S. Sousa, A.A.C.C. Pais.
Drug release from lipid liquid crystalline phases: relation with phase behaviour.
Drug Dev Ind Pharm (2010) 36, 470-481
34. E. Sparr, C. Åberg, P. Nilsson, H. Wennerström.
Diffusional transport in responding lipid membranes.
Soft Matter, (2009) 5, 3225-3233
33. C. Åberg, E, Sparr, K. Edler, H. Wennerström.
Non-Equilibrium Phase Transformations at the Air-Liquid Interface.
Langmuir (2009) 25, 12177–12184
32. F.O. Costa-Balogh, E. Sparr, J.J.S. Sousa, A.A.C.C Pais.
Drug release and skin permeation from lipid liquid crystalline phases.
Progr Coll Polym Sci (2008) 135, 119-129
31. C. Åberg, H. Wennerström, E. Sparr.
Langmuir (2008) 24, 8061-8070
30. C. Åberg, C. Pairin, F. Costa-Balogh, E. Sparr.
Responding Double-Porous Lipid Membranes.
Biochim. Biophys. Acta – Biomembranes (2007) 1778, 549-558
29. C.L. Silva, D. Topgaard, V. Kocherbitov, J.J.S. Sousa, A.A.C.C. Pais, E. Sparr.
Biochim. Biophys. Acta – Biomembranes (2007) 1768, 2647-2659
28. F. Costa-Balogh, H. Wennerström, L. Wadsö, E. Sparr.
J. Phys. Chem. B (2006) 110, 23845-23852
27. B. de Kruijff, J.A. Killian, D.N. Ganchev, H.A.Rinia, E. Sparr.
Striated domain self-organizing ordered assemblies of transmembrane a-helical peptides and lipids in bilayers.
Chem. Biol. (2005) 387, 235–241
26. E. Sparr, W.A. Ash, P.V.Nazarov, D.T.S. Rijkers, M.A. Hemminga, D.P. Tieleman, J.A. Killian.
Self-association of transmembrane a-helices in model membranes: importance of helix orientation and role of hydrophobic mismatch.
J. Biol. Chem . (2005) 280, 39324-39331
25. F. Costa-Balogh, C. Åberg, J.J. Sousa, E. Sparr.
Drug transport in responding lipid membranes can be regulated by an external osmotic gradient.
Langmuir, (2005) 21, 10307-10310
24. E. Sparr, D. Ganchev, A. Ridder, D. Rijkers, L. Kroon-Batenburg, V. Chupin, J.A. Killian, B. de Kruijff.
Molecular organization of striated domains formed by transmembrane a-helical peptides in dipalmitoylphosphatidylcholine bilayers.
Biochemistry (2005) 44, 2-10
23. E. Sparr, M.F.M. Engel, D.V. Sakharov, M. Sprong, J. Jacobs, B. de Kruijff, J.W.M. Höppener, J. A. Killian.
Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers.
FEBS Lett (2004) 577, 117–120
22. E. Sparr, P. Wadsten, V. Kocherbitov, S. Engström.
The effect of bacteriorhodopsin, detergent and hydration on the cubic-to-lamellar phase transition in the monoolein-distearoyl phosphatidyl glycerol-water system.
Biochim. Biophys Acta (2004) 1665, 156-165
21. N. Merclin, J. Bender, E. Sparr, H. Ehrsson, R. Guy, S. Engström.
Transdermal delivery from a lipid sponge phase –iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester.
J. Contr. Rel. (2004) 100, 191-198
20. A. Thapper, E. Sparr, B.F.G. Johnson, J. Lewis, P.R. Raithby, E. Norlander.
Reversible p-coordination of triallylphosphine in a trinuclear ruthenium carbonyl cluster.
Inorg. Chem. Comm. (2004) 7, 443-446
19. H. Wennerström, E. Sparr.
The Thermodynamics of Membrane Lipid Hydration.
Pure Appl. Chem. (2003) 75, 905-912
18. E. Sparr, L. Hallin, N. Markova, H. Wennerström.
Cholesterol-Phospholipid Bilayers under Osmotic Stress.
Biophys. J. (2002) 83, 2115-2125
17. H. Gillgren, A. Stenstam, E. Sparr, S. Ulvenlund.
Morphology and Molecular Conformation in Thin Films of Poly-g-methyl-L-glutamate at the Air-Water Interface.
Langmuir (2002) 18, 462-469
16. E. Sparr, H. Wennerström.
Responding Binary Phospholipid Membranes - Interplay between Hydration and Permeability.
Biophys. J. (2001) 81, 1014-1028
15. E. Sparr, L. Eriksson, J.A. Bouwstra , K. Ekelund.
An AFM Study on Lipid Monolayers: III. Phase Behaviour of Ceramides, Cholesterol and Fatty Acids.
Langmuir (2001) 17, 164-172
14. N. Markova, E. Sparr, L. Wadsö.
Applications of the Double Twin Isothermal Microcalorimeter – Phase Transformations and Clay Swelling.
Thermochim. Acta (2001) 374, 93-104
13. S. Ulvenlund, H. Gillgren, A. Stenstam, P. Bäckman, E. Sparr
Hydrophobic homopolymers of native a-L-amino acids at the air-water interface: A study by circular dichronism spectroscopy, atomic force microscopy, and surface balance experiments.
J. Colloid Interface Sci. (2001) 242, 346-353
12. E. Sparr, H. Wennerström.
Diffusion through a Responding Lamellar Liquid Crystal.
A Model of Molecular Transport across Stratum Corneum.
Colloids and Surfaces, B: Biointerfaces (2000) 19, 103-116
11. N. Markova, E. Sparr, L. Wadsö, H. Wennerström.
A Calorimetric Study of Phospholipid Hydration. Simultaneous Monitoring of Enthalpy and Free Energy.
J. Phys. Chem. B (2000) 104, 8053-8060
10. K. Ekelund, L. Eriksson, E. Sparr.
Rectangular Solid Domains in Ceramide-Cholesterol Monolayers- 2D Crystals.
Biochim. Biophys. Acta (2000) 1464, 1-6
9. S. Engström, K. Ekelund, J. Engblom, L. Eriksson, E. Sparr, H. Wennerström.
The Skin Barrier from a Lipid Perspective.
Acta Derm. Venerol. (2000) 208, 31-35
8. E.C. Constable, C.E. Housecroft, M. Neuburger, D. Philips, P.R. Raithby, E. Schofield, E. Sparr, D.A. Tocher, M. Zehnder, Y. Zimmermann.
Development of supramolecular structure through alkylation of pendant pyridyl functionality.
J. Chem. Soc. Dalton Trans. (2000) 13, 2219-2228
7. L.P. Clarke, J.E. Davies, P.R. Raithby, M.A. Rennie, G.P. Shields, E. Sparr.
Reaction of [Os3H2(CO)(10)] with the diyne Me3SiC2C2SiMe3 and the reactivity of the products towards [Co-2(CO)(8)]: the X-ray structures of [Os-3(m-H)(CO)(10){ m-z (1)- z (2)-HC2(SiMe3)C-2(SiMe3)}], [Os-3(m-CO)(CO)(9){ m (3)-z(2)-Me3SiC2C2SiMe3}] and [Os-3(m-H)(CO)(9){ m (3)- z (1): z (2)-; m-z(2)-Me3SiC2C2[Co-2(CO)(6)]}].
J. Organometallic Chem. (2000) 609, 169-176
6. E. Sparr, K. Ekelund, J. Engblom, S. Engström, H. Wennerström.
An AFM Study on Lipid Monolayers: II. The Effect of Cholesterol on Fatty Acids.
Langmuir (1999) 15, 6950-6955
5. K. Ekelund, E. Sparr, J. Engblom, H. Wennerström, S. Engström. An AFM Study on Lipid Monolayers: I. Pressure-Induced Phase Behaviour of Plain and Mixed Fatty Acids.
Langmuir (1999) 15, 6946-6949
4. F.H. Allen, C.A. Baalham, J.P.M. Lommerse, P.R. Raithby, E. Sparr.
Hydrogen-bond acceptor properties of nitro-O atoms: a combined crystallographic database and ab initio molecular orbital study.
Acta Cryst. (1997) B53, 1017-1024
BOOK CHAPTERS
3. E Sparr.
Sju stora beslut och tre små tips. Chapter in antholgy “Vägar till vetenskapen”, Editor K. Nordlund. Santérus förlag (2013)
2. E. Sparr.
Osynlig rörelse. Chapter in interdisciplinary antholgy “TEMPO”, Editors H. Sandberg, M. Cronqvist. Makadam förlag (2008)
1. E. Sparr, S. Engström.
Lipid Phase Behaviour – Basis for an Understanding of Membrane Structure and Function. Book chapter in ‘Hair; Nail and Skin: Structure and function’ (Eds. B. Forslind, M. Lindberg, Marcel Dekker). 2004