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Physical Chemistry

Lund University

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Karin Schillén, Professor

Research interests

Self-assembly and phase behavior of amphiphilic block copolymers, electrostatically driven co-assembly of oppositely charged copolymers, interactions of stimuli-responsive block copolymers/polyelectrolytes/biopolymers with bile salts and surfactants. Formation of supramolecular structures of bile salt derivatives. Main methods of investigation: dynamic and static light scattering, small angle X-ray scattering, differential scanning and titration calorimetry, cryogenic transmission electron microscopy.

Research projects

  • Soluble complex salts of surfactant ions and polymeric counterions: Composite macromolecular self-assembly
  • PEO-PPO-PEO (Pluronic®/Synperonic®) block copolymer systems. Physico-chemical studies of the self-assembly of PEO-PPO-PEO triblock copolymers and their interaction with surfactants, bile salts and polyelectrolytes in aqueous solution.

Academic background

2008 Professor of Physical Chemistry – Surface and Colloid Chemistry, Lund University

2002 Docent in Physical Chemistry, Lund University

1996–1997 Postdoctoral Fellow (Swedish Research Council, VR), University of Toronto, Dept. of Chemistry, Canada. Project: "Fluorescence spectroscopy on fluorescently labelled block copolymers"

1994–1996 Postdoctoral Fellow, Royal Institute of Technology (KTH), Sweden. Project: "Surface force measurements on block copolymers"

1994 PhD in Physical Chemistry, Uppsala University, Thesis: "Solution properties of block copolymers studied using light scattering". Supervised by Prof. Wyn Brown

1989 Master of Science (MSc) in Physics and Chemistry, Uppsala University

Faculty positions

2019 Visiting Professor (Guest professorship), Department of Chemistry, La Sapienza University of Rome

2008–present Professor, Division of Physical Chemistry, Lund University

2003–2008 Associate Professor/Senior Lecturer, Division of Physical Chemistry, Lund University

1997–2003 Assistant Professor, Division of Physical Chemistry, Lund University

Research programs and networks

2018–2021  Swedish coordinator of a Joint China-Sweden Mobility Program with Institute of Chemistry, Chinese Academy of Science, Beijing from The Swedish Foundation for International Cooperation Research and Higher Education (STINT)

2006–2016 Member of the Linnaeus Center of Excellence Organzing Molecular Matter (OMM) through the Swedish Research Council

2003–2007 Member of the Swedish Foundation for Strategic Research (SSF) program Colloidal Structures from Self-association (COLINTECH)

1998–2005 Member of the Competence Centre for Amphiphilic Polymers from Renewable Resources (CAP) through VINNOVA

Graduate students brought to PhD

Guanqun Du (current)

2016 Solmaz Bayati, Thesis: "Mixed Block Copolymer Solutions: Self-Assembly and Interactions"

2012 Johan Janiak, Thesis: "Phase Behavior and Solution Properties of Aqueous Polyion-Surfactant Ion Systems"

2009 Telma Costa, Thesis: "Photophysics of Macromolecular Pyrene-Containing Systems" (exchange PhD student, Department of Chemistry, Coimbra University, co-supervisor. Main supervisor: Sérgio Seixas de Melo)

2008 David Löf, Thesis: "Scattering Studies of Macromolecules in Solution"

2004 Karin Bryskhe, Thesis: "Formation of Block Copolymer and Surfactant Vesicles"

2004 Jörgen Jansson, Thesis: "The Interaction between Triblock Copolymers and Surfactants in Dilute Aqueous Solution"

Past postdoctoral researchers

2004 Dmitri Pebalk

2009–2010 Guiseppe Lazzara

Past undergraduate students and visiting PhD students

2020 Suelen Gauna Trindade (visiting PhD student, University of Campinas (UNICAMP), Brazil)

2018-2020 Marco Fornasier (visiting PhD student, University of Cagliari, Italy)

2016 Jacopo Cautela (visiting PhD student, La Sapienza Rome University, Italy)

2014 Veronica Lattanzi (Eramus internship, La Sapienza Rome University, Italy)

2014 Marta Gubitosi (visiting PhD student, La Sapienza Rome University, Italy)

2014 Valeria Meli (visiting PhD student, University of Cagliari, Italy)

2014 Caroline Anderberg Haglund, MSc thesis: "Interaction between PEO-PPO-PEO Block Copolymers and a Bile Salt"

2013 Marta Gubitosi (visiting PhD student, La Sapienza Rome University, Italy)

2009 Michael Fuchs, BSc thesis: "How Polydispersity of PEO-PPO-PEO Block Copolymers Affects the Mesoporous Silica Materials"

2007 John Janiak, MSc thesis: "DNA-PAMAM Dendrimer Complex formation Studied using Light Scattering and Steady-State Fluorescence Spectroscopy"

2005 Ikes Montes, MSc thesis: "A Study of PEO-PPO-PEO Triblock Copolymers: L121-F127-Water Phase Behavior, Vesicle Formation and Characterization" (Erasmus student, University of Basque Country, Spain)

2003 Telma Costa (Eramus internship, Coimbra University, Portugal)

2000–2002 Rodrigo Cardoso da Silva (visiting PhD student, Campinas University (UNICAMP), Brazil)

2002 Anna Niemiec (Erasmus internship, Krakow University, Poland)

Teaching

2007–present Head teacher in Physical Chemistry

Publications

94. Fornasier, M.; Pireddu, R.; Del Giudice, A.; Sinico, C.; Nylander, T.; Schillén, K.; Galantini, L.; Murgia, S., Tuning Lipid Structure by Bile Salts: Hexosomes for Topical Administration of Catechin. Colloids Surf., B 2021, 111564

93. Cautela, J.; Stenqvist, B.; Schillén, K.; Belić, D.; Månsson, L.; Hagemans, F.; Seuss, M.; Fery, A.; Crassous, J.; Galantini, L., Supracolloidal Atomium. ACS Nano 2020, 14, 15748–15756, DOI: 10.1021/acsnano.0c06764

92. Fornasier, M.; Porcheddu, A.; Casu, A.; Raghavan, S. R.; Jönsson, P.; Schillén, K.; Murgia, S., Surface-Modified Nanoerythrosomes for Potential Optical Imaging Diagnostics. J. Colloid Interface Sci. 2021, 582, 246-253. DOI: 10.1016/j.jcis.2020.08.032  

91. Du, G.; Del Giudice, A.; Alfredsson, V.; Carnerup, A. M.; Pavel, N. V.; Loh, W.; Masci, G.; Nyström, B.; Galantini, L.;  Schillén, K., Effect of Temperature on the Association Behavior in Aqueous Mixtures of an Oppositely Charged Amphiphilic Block Copolymer and Bile Salt. Polymer 2020, 206, 122871. DOI: 10.1016/j.polymer.2020.122871

90. Tasca, E.; Andreozzi, P.; Del Giudice, A.; Galantini, L.; Schillén, K.; Giuliani, A. M.; los Angeles Ramirez, M.; Moya, S.; Giustini, M., Poloxamer/Sodium Cholate Co-Formulation for Micellar Encapsulation of Doxorubicin with High Efficiency for Intracellular Delivery: An In-Vitro Bioavailability Study. J. Colloid Interface Sci. 2020, 579, 551-561. DOI: 10.1016/j.jcis.2020.06.096

89. Cautela, J.; Severoni, E.; Redondo-Gómez, C.; di Gregorio, M. C.; Del Giudice, A.; Sennato, S.; Angelini, R.; D’Abramo, M.; Schillén, K.; Galantini, L., C-12 vs C-3 Substituted Bile Salts: An Example of the Effects of Substituent Position and Orientation on the Self-Assembly of Steroid Surfactant Isomers. Colloids Surf., B 2020, 185, 110556. DOI: 10.1016/j.colsurfb.2019.110556

88. Schillén, K.; Galantini, L.; Du, G.; Del Giudice, A.; Alfredsson, V.; Carnerup, A. M.; Pavel, N. V.; Masci, G.; Nyström, B., Block Copolymers as Sequestrants: Intriguing Structures Formed in a Mixture of an Oppositely Charged Amphiphilic Block Copolymer and Bile Salt. Phys. Chem. Chem. Phys., 2019, 21, 12518-12529. DOI: 10.1039/c9cp01744e

87. Tasca, E.; Del Giudice, A.; Galantini, L.; Schillén, K.; Giuliani, A. M.; Giustini, M., A Fluorescence Study of the Loading and Time Stability of Doxorubicin in Sodium Cholate/PEO-PPO-PEO Triblock Copolymer Mixed Micelles. J. Colloid Int. Sci. 2019, 540, 593-601. DOI: 10.1016/j.jcis.2019.01.075

86. Travaglini, L.; Giordano, C.; D'Annibale, A.; Gubitosi, M.; di Gregorio, M. C.; Schillén, K.; Stefanucci, A.; Mollica, A.; Pavel, N. V.; Galantini, L., Twisted Nanoribbons from a RGD-bearing Cholic Acid Derivative. Colloids Surf. B 2017, 159, 183-190. DOI: 10.1016/j.colsurfb.2017.07.084

85. Bayati, S.; Bergquist, K.-E.; Zhu, K.; Nyström, B.; Pedersen, J. S.; Galantini, L.; Schillén, K., Mixed Micelles of Oppositely Charged Poly(N-isopropylacrylamide) Diblock Copolymers. J. Polym. Sci. B Polym. Phys. 2017, 55 (19), 1457-1469. DOI: 10.1002/polb.24403

84. Lazzara, G.; Campbell, R. A.; Bayati, S.; Zhu, K.; Nyström, B.; Nylander, T.; Schillén, K., On the Formation of Inclusion Complexes at the Solid/Liquid Interface of Anchored Temperature-Responsive PNIPAAM Diblock Copolymers with γ-Cyclodextrin. Colloid Polym. Sci. 2017, 295 (8), 1327-1341. DOI: 10.1007/s00396-017-4052-6

83. Gubitosi, M.; D’Annibale, A.; Schillén, K.; Olsson, U.; Pavel, N. V.; Galantini, L., On the Stability of Lithocholate Derivative Supramolecular Tubules. RSC Adv. 2017, 7, 512-517. DOI: 10.1039/C6RA26092F

82. Galantini, L.; di Gregorio, M. C.; Gubitosi, M.; Travaglini, L.; Pavel, N. V.; Jover, A.; Meijide, F.; Tato, J. V.; Sennato, S.; Schillén, K.; De Santis, S.; Tranchini, F.; Masci, G., Supramolecular Assembly of a Thermoresponsive Steroidal Surfactant with an Oppositely Charged Thermoresponsive Block Copolymer. Phys. Chem. Phys. Chem. 2017, 19 (2), 1504-1515. DOI: 10.1039/C6CP05665B

81. Bayati, S.; Haglund, C. A.; Pavel, N.; Galantini, L.; Schillén, K., Interaction between Bile Salt Sodium Glycodeoxycholate and PEO–PPO–PEO Triblock Copolymers in Aqueous Solution. RSC Adv. 2016, 6, 69313-69325. DOI: 10.1039/C6RA12514J

80. Bayati, S.; Galantini, L.; Knudsen, K. D.; Schillén, K., Complexes of PEO-PPO-PEO Triblock Copolymer P123 and Bile Salt Sodium Glycodeoxycholate in Aqueous Solution: A Small Angle X-Ray and Neutron Scattering Investigation. Colloids Surf., A 2016, 504, 426-436. DOI: 10.1016/j.colsurfa.2016.05.096

79. Travaglini, L.; Gubitosi, M.; di Gregorio, M. C.; D’Annibale, A.; Meijide, F.; Giustini, M.; Sennato, S.; Obiols-Rabasa, M.; Schillén, K.; Pavel, N. V., A Tryptophan-Substituted Cholic Acid: Expanding the Family of Labelled Biomolecules. Colloids Surf., A 2015, 483, 142-149. DOI: 10.1016/j.colsurfa.2015.03.033

78. Murgia, S.; Falchi, A. M.; Meli, V.; Schillén, K.; Lippolis, V.; Monduzzi, M.; Rosa, A.; Schmidt, J.; Talmon, Y.; Bizzarri, R., Cubosome Formulations Stabilized by a Dansyl-Conjugated Block Copolymer for Possible Nanomedicine Applications. Colloids Surf., B 2015, 129, 87-94. DOI: 10.1016/j.colsurfb.2015.03.025

77. Gubitosi, M.; Travaglini, L.; Di Gregorio, M. C.; Pavel, N. V.; Vázquez Tato, J.; Sennato, S.; Olsson, U.; Schillén, K.; Galantini, L., Tailoring Supramolecular Nanotubes by Bile Salt Based Surfactant Mixtures. Angew. Chem. Int. Ed. 2015, 54 (24), 7018-7021. DOI: 10.1002/anie.201500445

76. Bayati, S.; Galantini, L.; Knudsen, K. D.; Schillén, K., Effects of Bile Salt Sodium Glycodeoxycholate on the Self-Assembly of PEO–PPO–PEO Triblock Copolymer P123 in Aqueous Solution. Langmuir 2015, 31 (50), 13519-13527. DOI: 10.1021/acs.langmuir.5b03828

75. Yanez Arteta, M.; Campbell, R. A.; Watkins, E. B.; Obiols-Rabasa, M.; Schillén, K.; Nylander, T., Interactions of Small Dendrimers with Sodium Dodecyl Sulfate at the Air–Water Interface. J. Phys. Chem. B 2014, 118 (40), 11835-11848. DOI: 10.1021/jp507230m

74. Janiak, J.; Tomšič, M.; Lundberg, D.; Olofsson, G.; Piculell, L.; Schillén, K., Soluble Aggregates in Aqueous Solutions of Polyion–Surfactant Ion Complex Salts and a Nonionic Surfactant. J. Phys. Chem. B 2014, 118 (32), 9745-9756. DOI: 10.1021/jp411701g (selected for journal cover)

73. Gubitosi, M.; Travaglini, L.; D’Annibale, A.; Pavel, N. V.; Vazquez Tato, J.; Obiols-Rabasa, M.; Sennato, S.; Olsson, U.; Schillén, K.; Galantini, L., Sugar–Bile Acid-Based Bolaamphiphiles: From Scrolls to Monodisperse Single-Walled Tubules. Langmuir 2014, 30 (22), 6358-6366. DOI: 10.1021/la500908r

72. Travaglini, L.; D’Annibale, A.; Di Gregorio, M. C.; Schillén, K.; Olsson, U.; Sennato, S.; Pavel, N. V.; Galantini, L., Between Peptides and Bile Acids: Self- Assembly of Phenylalanine Substituted Cholic Acids. J. Phys. Chem. B 2013, 117 (31), 9248-9257. DOI: 10.1021/jp405342v

71. Percebom, A. M.; Janiak, J.; Schillén, K.; Piculell, L.; Loh, W., Micellization of Water-Soluble Complex Salts of an Ionic Surfactant with Hairy Polymeric Counterions. Soft Matter 2013, 9 (2), 515-526. DOI: 10.1039/C2SM26683K

70. Janiak, J.; Piculell, L.; Schillén, K.; Lundberg, D., Responsive Release of Polyanions from Soluble Aggregates Formed with a Hydrolyzable Cationic Surfactant and a Nonionic Surfactant. Soft Matter 2013, 9 (15), 4103-4112. DOI: 10.1039/C3SM27315F 

69. di Gregorio, M. C.; Pavel, N. V.; Jover, A.; Meijide, F.; Tato, J. V.; Tellini, V. H. S.; Vargas, A. A.; Regev, O.; Kasavi, Y.; Schillén, K., pH Sensitive Tubules of a Bile Acid Derivative: A Tubule Opening by Release of Wall Leaves. Phys. Chem. Chem. Phys. 2013, 15 (20), 7560-7566. DOI: 10.1039/C3CP00121K

68. Travaglini, L.; D’Annibale, A.; Schillén, K.; Olsson, U.; Sennato, S.; Pavel, N. V.; Galantini, L., Amino Acid-Bile Acid Based Molecules: Extremely Narrow Surfactant Nanotubes Formed by a Phenylalanine-Substituted Cholic Acid. Chem. Commun. 2012, 48, 12011-12013. DOI: 10.1039/C2CC36030F

67. Lazzara, G.; Alfredsson, V.; Olofsson, G.; Zhu, K.; Nyström, B.; Schillén, K., Temperature-Responsive Inclusion Complex of Cationic PNIPAAM Diblock Copolymer and γ–Cyclodextrin. Soft Matter 2012, 8, 5043-5054. DOI: 10.1039/C2SM07252A

66. Janiak, J.; Bayati, S.; Galantini, L.; Pavel, N. V.; Schillén, K., Nanoparticles with Bicontinuous Cubic Internal Structure Formed by Cationic and Nonionic Surfactants and an Anionic Polyelectrolyte. Langmuir 2012, 28 (48), 16536-16546. DOI: 10.1021/la303938k

65. Lundberg, D.; Carnerup, A. M.; Janiak, J.; Schillén, K.; Miguel, M. D.; Lindman, B., Size and Morphology of Assemblies Formed by DNA and Lysozyme in Dilute Aqueous Mixtures. Phys. Chem. Phys. Chem. 2011, 13 (8), 3082-3091. DOI: 10.1039/c0cp01220c

64. Long, Y. Y.; Philip, J. Y. N.; Schillén, K.; Liu, F.; Ye, L., Insight into Molecular Imprinting in Precipitation Polymerization Systems Using Solution NMR and Dynamic Light Scattering. J. Mol. Recognit. 2011, 24 (4), 619-630. DOI: 10.1002/jmr.1097

63. Löf, D.; Schillén, K.; Nilsson, L., Flavonoids: Precipitation Kinetics and Interaction with Surfactant Micelles. J. Food Sci. 2011, 76 (3), N35-N39. DOI: 10.1111/j.1750-3841.2011.02103.x

62. Janiak, J.; Piculell, L.; Olofsson, G.; Schillén, K., The Aqueous Phase Behavior of Polyion-Surfactant Ion Complex Salts Mixed with Nonionic Surfactants. Phys. Chem. Phys. Chem. 2011, 13 (8), 3126-3138. DOI: 10.1039/c0cp01031f

61. Törnvall, U.; Hedström, M.; Schillén, K.; Hatti-Kaul, R., Structural, Functional and Chemical Changes in Pseudozyma Antarctica Lipase B on Exposure to Hydrogen Peroxide. Biochimie 2010, 92 (12), 1867-1875. DOI: 10.1016/j.biochi.2010.07.008

60. Lundberg, D.; Carnerup, A. M.; Schillén, K.; Miguel, M. D.; Lindman, B., Phase Behavior and Coassembly of DNA and Lysozyme in Dilute Aqueous Mixtures: A Model Investigation of DNA-Protein Interactions. Langmuir 2010, 26 (5), 2986-2988. DOI: 10.1021/la904104w

59. Balogh, J.; Olsson, U.; Pedersen, J. S.; Kaper, H.; Wennerström, H.; Schillén, K.; Miguel, M., Nonionic Microemulsions: Dependence of Oil-Chain Length and Active Component (Lidocaine). In Self-Organized Surfactant Structures, Tadros, T. F., Ed. John Wiley & Sons Ltd: Oxford, 2010, p 59-87. DOI: 10.1002/9783527632633.ch3

58. Vaccaro, M.; Mangiapia, G.; Radulescu, A.; Schillén, K.; D'Errico, G.; Morelli, G.; Paduano, L., Colloidal Particles Composed of Amphiphilic Molecules Binding Gadolinium Complexes and Peptides as Tumor-Specific Contrast Agents in MRI: Physico-Chemical Characterization. Soft Matter 2009, 5 (13), 2504-2512. DOI: 10.1039/b820804b

57. Löf, D.; Tomšič, M.; Glatter, O.; Fritz-Popovski, G.; Schillén, K., Structural Characterization of Nonionic Mixed Micelles Formed by C12EO6 Surfactant and P123 Triblock Copolymer. J. Phys. Chem. B 2009, 113 (16), 5478-5486. DOI: 10.1021/jp808442d

56. Costa, T.; Schillén, K.; Miguel, M. D.; Lindman, B.; de Melo, J. S., Association of a Hydrophobically Modified Polyelectrolyte and a Block Copolymer Followed by Fluorescence Techniques. J. Phys. Chem. B 2009, 113 (18), 6194-6204. DOI: 10.1021/jp8093879

55. Costa, T.; de Melo, J. S.; Miguel, M. D.; Lindman, B.; Schillén, K., Complex Formation between a Fluorescently-Labeled Polyelectrolyte and a Triblock Copolymer. J. Phys. Chem. B 2009, 113 (18), 6205-6214. DOI: 10.1021/jp8093885

54. Burrows, H. D.; Tapia, M. J.; Fonseca, S. M.; Pradhan, S.; Scherf, U.; Silva, C. L.; Pais, A.; Valente, A. J. M.; Schillén, K.; Alfredsson, V.; Carnerup, A. M.; Tomsic, M.; Jamnik, A., Solubilization of Poly{1,4-Phenylene- 9,9-Bis(4-Phenoxy-Butylsulfonate) Fluorene-2,7-Diyl} in Water by Nonionic Amphiphiles. Langmuir 2009, 25 (10), 5545-5556. DOI: 10.1021/la8042044

53. Ainalem, M. L.; Carnerup, A. M.; Janiak, J.; Alfredsson, V.; Nylander, T.; Schillén, K., Condensing DNA with Poly(Amido Amine) Dendrimers of Different Generations: Means of Controlling Aggregate Morphology. Soft Matter 2009, 5 (11), 2310-2320. DOI: 10.1039/b821629k

52. Schillén, K.; Jansson, J.; Löf, D.; Costa, T., Mixed Micelles of a PEO-PPO-PEO Triblock Copolymer (P123) and a Nonionic Surfactant (C12EO6) in Water. A Dynamic and Static Light Scattering Study. J. Phys. Chem. B 2008, 112 (18), 5551-5562. DOI: 10.1021/jp074832w

51. Gaweda, S.; Moran, M. C.; Pais, A.; Dias, R. S.; Schillén, K.; Lindman, B.; Miguel, M. G., Cationic Agents for DNA Compaction. J. Colloid Interface Sci. 2008, 323 (1), 75-83. DOI: 10.1016/j.jcis.2008.04.006

50. Cardenas, M.; Schillén, K.; Alfredsson, V.; Duan, R. D.; Nyberg, L.; Amebrant, T., Solubilization of Sphingornyelin Vesicles by Addition of a Bile Salt. Chem. Phys. Lipids 2008, 151 (1), 10-17. DOI: 10.1016/j.chemphyslip.2007.09.002

49. Vaccaro, M.; Accardo, A.; D'Errico, G.; Schillén, K.; Radulescu, A.; Tesauro, D.; Morelli, G.; Paduano, L., Peptides and Gd Complexes Containing Colloidal Assemblies as Tumor-Specific Contrast Agents in MRI: Physicochemical Characterization. Biophys. J. 2007, 93 (5), 1736-1746. DOI: 10.1529/biophysj.107.107417

48. Torres, M. F.; Gonzalez, J. M.; Rojas, M. R.; Muller, A. J.; Saez, A. E.; Löf, D.; Schillén, K., Effect of Ionic Strength on the Rheological Behavior of Aqueous Cetyltrimethylammonium p-Toluene Sulfonate Solutions. J. Colloid Interface Sci. 2007, 307 (1), 221-228. DOI: 10.1016/j.jcis.2006.11.002

47. Tesauro, D.; Accardo, A.; Gianolio, E.; Paduano, L.; Teixeira, J.; Schillén, K.; Aime, S.; Morelli, G., Peptide Derivatized Lamellar Aggregates as Target-Specific MRI Contrast Agents. Chem. Bio. Chem 2007, 8 (8), 950-955. DOI: 10.1002/cbic.200700077

46. Örberg, M. L.; Schillén, K.; Nylander, T., Dynamic Light Scattering and Fluorescence Study of the Interaction between Double-Stranded DNA and Poly(Amido Amine) Dendrimers. Biomacromolecules 2007, 8 (5), 1557-1563. DOI: 10.1021/bm061194z

45. Örberg, M. L.; Nylander, T.; Schillén, K., Characterisation of the Aggregate Formation between Linear DNA and Poly(Amidoamine) Dendrimers. Biophys. J. 2007, Suppl. S, 44A. ISSN: 0006-3495

44. Löf, D.; Schillén, K.; Torres, M. F.; Muller, A. J., Rheological Study of the Shape Transition of Block Copolymer-Nonionic Surfactant Mixed Micelles. Langmuir 2007, 23 (22), 11000-11006. DOI: 10.1021/la701818y

43. Löf, D.; Schillén, K.; Jönsson, B.; Evilevitch, A., Forces Controlling the Rate of DNA Ejection from Phage Lambda. J. Mol. Biol. 2007, 368 (1), 55-65. DOI: 10.1016/j.jmb.2007.01.076

42. Löf, D.; Schillén, K.; Jönsson, B.; Evilevitch, A., Dynamic and Static Light Scattering Analysis of DNA Ejection from the Phage Lambda. Phys. Rev. E 2007, E76, 011914. DOI: 10.1103/PhysRevE.76.011914 

41. Löf, D.; Niemiec, A.; Schillén, K.; Loh, W.; Olofsson, G., A Calorimetry and Light Scattering Study of the Formation and Shape Transition of Mixed Micelles of EO20PO68EO20 Triblock Copolymer (P123) and Nonionic Surfactant (C12EO6). J. Phys. Chem. B 2007, 111 (21), 5911-5920. DOI: 10.1021/jp071101n

40. de Melo, J. S. S.; Costa, T.; Oliveira, N.; Schillén, K., Fluorescence Studies on the Interaction between Pyrene-Labelled Poly(Acrylic Acid) and Cyclodextrins. Polymer Int. 2007, 56 (7), 882-899. DOI: 10.1002/pi.2219

39. Accardo, A.; Tesauro, D.; Morelli, G.; Gianolio, E.; Aime, S.; Vaccaro, M.; Mangiapia, G.; Paduano, L.; Schillén, K., High-Relaxivity Supramolecular Aggregates Containing Peptides and Gd Complexes as Contrast Agents in MRI. J. Biol. Inorg. Chem. 2007, 12 (2), 267-276. DOI: 10.1007/s00775-006-0186-6

38. Vaccaro, M.; Accardo, A.; Tesauro, D.; Mangiapia, G.; Löf, D.; Schillén, K.; Söderman, O.; Morelli, G.; Paduano, L., Supramolecular Aggregates of Amphiphilic Gadolinium Complexes as Blood Pool MRI/MRA Contrast Agents: Physicochemical Characterization. Langmuir 2006, 22 (15), 6635-6643. DOI: 10.1021/la053500k

37. Santos, O.; Nylander, T.; Schillén, K.; Paulsson, M.; Trägårdh, C., Effect of Surface and Bulk Solution Properties on the Adsorption of Whey Protein onto Steel Surfaces at High Temperature. J. Food Eng. 2006, 73 (2), 174-189. DOI: 10.1016/j.jfoodeng.2005.01.018

36. Cardenas, M.; Barauskas, J.; Schillén, K.; Brennan, J. L.; Brust, M.; Nylander, T., Thiol-Specific and Nonspecific Interactions between DNA and Gold Nanoparticles. Langmuir 2006, 22 (7), 3294-3299.  DOI: 10.1021/la0530438

35. Samoshina, Y.; Nylander, T.; Claesson, P.; Schillén, K.; Iliopoulos, I.; Lindman, B., Adsorption and Aggregation of Cationic Amphiphilic Polyelectrolytes on Silica. Langmuir 2005, 21 (7), 2855-2864. DOI: 10.1021/la047311y

34. Löf, D.; Schillén, K.; Olofsson, G.; Lindman, B.; Loh, W.; Niemiec, A.; Torres, M.; Müller, A. J., The Shape Transition of Block Copolymer/Nonionic Surfactant Complexes. In XI Coloquio Venezolano de Polímeros, SABER-ULA Universidad de Los Andes Venezuela: Caracas, 2005; 63-64.

33. Jansson, J.; Schillén, K.; Nilsson, M.; Söderman, O.; Fritz, G.; Bergmann, A.; Glatter, O., Small-Angle X-Ray Scattering, Light Scattering, and NMR Study of PEO-PPO-PEO Triblock Copolymer/Cationic Surfactant Complexes in Aqueous Solution. J. Phys. Chem. B 2005, 109 (15), 7073-7083. DOI: 10.1021/jp0468354

32. Costa, T.; Schillén, K.; Miguel, M. G.; Lindman, B.; de Melo, J. S., Study of the Interaction between a Polyelectrolyte Randomly Labeled with Pyrene and a PEO-PPO-PEO Triblock Copolymer Using Fluorescence and Dynamic Light Scattering. In Coloides e Interfases, Velazques, M. M.; Merchan, M. D., Eds. Ediciones Universidad de Salamanca: Salamanca, 2005; 313-319.

31. Costa, T.; Miguel, M. G.; Lindman, B.; Schillén, K.; Lima, J. C.; de Melo, J. S., Self-Assembly of a Hydrophobically Modified Naphthalene-Labeled Poly(Acrylic Acid) Polyelectrolyte in Water: Organic Solvent Mixtures Followed by Steady-State and Time-Resolved Fluorescence. J. Phys. Chem. B 2005, 109 (8), 3243-3251. DOI: 10.1021/jp046589w

30. Costa, T.; Miguel, M. D.; Lindman, B.; Schillén, K.; de Melo, J. S. S., Dynamics and Energetics of the Self-Assembly of a Hydrophobically Modified Polyelectrolyte: Naphthalene-Labeled Poly(Acrylic Acid). J. Phys. Chem. B 2005, 109 (23), 11478-11492. DOI: 10.1021/jp050236v

29. Cardenas, M.; Schillén, K.; Pebalk, D.; Nylander, T.; Lindman, B., Interaction between DNA and Charged Colloids Could Be Hydrophobically Driven. Biomacromolecules 2005, 6 (2), 832-837. DOI: 10.1021/bm049422h

28. Bryskhe, K.; Schillén, K.; Olsson, U.; Yaghmur, A.; Glatter, O., Formation of Internally Nanostructured Triblock Copolymer Particles. Langmuir 2005, 21 (19), 8597-8600. DOI: 10.1021/la051157d

27. Jansson, J.; Schillén, K.; Olofsson, G.; da Silva, R. C.; Loh, W., The Interaction between PEO-PPO-PEO Triblock Copolymers and Ionic Surfactants in Aqueous Solution Studied Using Light Scattering and Calorimetry. J. Phys. Chem. B 2004, 108 (1), 82-92. DOI: 10.1021/jp030792u

26. Cardenas, M.; Schillén, K.; Nylander, T.; Jansson, J.; Lindman, B., DNA Compaction by Cationic Surfactant in Solution and at Polystyrene Particle Solution Interfaces: A Dynamic Light Scattering Study. Phys. Chem. Phys. Chem. 2004, 6 (7), 1603-1607. DOI: 10.1039/b310798a

25. Bryskhe, K.; Jansson, J.; Topgaard, D.; Schillén, K.; Olsson, U., Spontaneous Vesicle Formation in a Block Copolymer System. J. Phys. Chem. B 2004, 108 (28), 9710-9719. DOI: 10.1021/jp031313u

24. Nilsson, A.; Neves-Petersen, M. T.; Johansson, H. O.; Jansson, J.; Schillén, K.; Tjerneld, F.; Petersen, S. B., Tryptophan-Tagged Cutinase Studied by Steady State Fluorescence for Understanding of Tag Interactions in Aqueous Two-Phase Systems. Biochim. Biophys. Acta-Proteins Proteome. 2003, 1646 (1-2), 57-66. DOI: 10.1016/s1570-9639(02)00550-2

23. de Melo, J. S.; Costa, T.; Miguel, M. D.; Lindman, B.; Schillén, K., Time-Resolved and Steady-State Fluorescence Studies of Hydrophobically Modified Water-Soluble Polymers. J. Phys. Chem. B 2003, 107 (46), 12605-12621. DOI: 10.1021/jp0346054

22. da Silva, R. C.; Olofsson, G.; Schillén, K.; Loh, W., Influence of Ionic Surfactants on the Aggregation of Poly(Ethylene Oxide)-Poly(Propylene Oxide)- Poly(Ethylene Oxide) Block Copolymers Studied by Differential Scanning and Isothermal Titration Calorimetry. J. Phys. Chem. B 2002, 106 (6), 1239-1246. DOI: 10.1021/jp012729f

21. Bryskhe, K.; Schillén, K.; Löfroth, J. E.; Olsson, U., Lipid-Block Copolymer Immiscibility. Phys. Chem. Phys. Chem. 2001, 3 (7), 1303-1309. DOI: 10.1039/b009487k

20. Schillén, K.; Anghel, D. F.; Miguel, M. D.; Lindman, B., Association of Naphthalene-Labeled Poly(Acrylic Acid) and Interaction with Cationic Surfactants. Fluorescence Studies. Langmuir 2000, 16 (26), 10528-10539. DOI: 10.1021/la000943+

19. Schillén, K.; Yekta, A.; Ni, S. R.; Farinha, J. P. S.; Winnik, M. A., Characterization of Polyisoprene-B-Poly(Methyl Methacrylate) Diblock Copolymer Micelles in Acetonitrile. J. Phys. Chem. B 1999, 103 (43), 9090-9103. DOI: 10.1021/jp990251y

18. Schillén, K.; Yekta, A.; Ni, S.; Winnik, M. A., Characterization by Fluorescence Energy Transfer of the Core of Polyisoprene-Poly(Methyl Methacrylate) Diblock Copolymer Micelles. In Trends in Colloid and Interface Science XIII. Tezak, D.; Martinis, M., Eds. 1999; 112, p 45-48. DOI: 10.1007/3-540-48953-3_10

17. Schillén, K.; Bryskhe, K.; Mel'nikova, Y. S., Vesicles Formed from a Poly(Ethylene Oxide)-Poly(Propylene Oxide)-Poly(Ethylene Oxide) Triblock Copolymer in Dilute Aqueous Solution. Macromolecules 1999, 32 (20), 6885-6888. DOI: 10.1021/ma9908144

16. Farinha, J. P. S.; Schillén, K.; Winnik, M. A., Interfaces in Self-Assembling Diblock Copolymer Systems: Characterization of Poly(Isoprene-B-Methyl Methacrylate) Micelles in Acetonitrile. J. Phys. Chem. B 1999, 103 (13), 2487-2495. DOI: 10.1021/jp9843858

15. Schillén, K.; Yekta, A.; Ni, S. R.; Winnik, M. A., Characterization by Fluorescence Energy Transfer of the Core of Polyisoprene- Poly(Methylmethacrylate) Diblock Copolymer Micelles. Strong Segregation in Acetonitrile. Macromolecules 1998, 31 (1), 210-212. DOI: 10.1021/ma971289g

14. Kitaev, V.; Schillén, K.; Kumacheva, E., Supramolecular Structures of Poly(Gamma-Benzyl-L-Glutamate) Self-Assembled on Mica Surface. J. Polym. Sci. Part B: Polym. Phys. 1998, 36 (9), 1567-1577.

13. Fielden, M. L.; Claesson, P. M.; Schillén, K., Investigation of a 31% Charged Cationic Polyelectrolyte Interacting with Sodium Dodecyl Sulfate in Bulk Solution and as a Preadsorbed Layer on Mica. Low Ionic Strength. Langmuir 1998, 14 (19), 5366-5375. DOI: 10.1021/la980456i

12. Schillén, K.; Claesson, P. M.; Malmsten, M.; Linse, P.; Booth, C., Properties of Poly(Ethylene Oxide)-Poly(Butylene Oxide) Diblock Copolymers at the Interface between Hydrophobic Surfaces and Water. J. Phys. Chem. B 1997, 101 (21), 4238-4252. DOI: 10.1021/jp963193e

11. Jorgensen, E. B.; Hvidt, S.; Brown, W.; Schillén, K., Effects of Salts on the Micellization and Gelation of a Triblock Copolymer Studied by Rheology and Light Scattering. Macromolecules 1997, 30 (8), 2355-2364. DOI: 10.1021/ma9616322

10. Schillén, K.; Brown, W.; Johnsen, R. M., Micellar Sphere-to-Rod Transition in an Aqueous Triblock Copolymer System. A Dynamic Light Scattering Study of Translational and Rotational Diffusion. Macromolecules 1994, 27 (17), 4825-4832. DOI: 10.1021/ma00095a025

9. Hvidt, S.; Jorgensen, E. B.; Brown, W.; Schillén, K., Micellization and Gelation of Aqueous Solutions of a Triblock Copolymer Studied by Rheological Techniques and Scanning Calorimetry. J. Phys. Chem. 1994, 98 (47), 12320-12328. DOI: 10.1021/j100098a030

8. Glatter, O.; Scherf, G.; Schillén, K.; Brown, W., Characterization of a Poly(Ethylene Oxide)-Poly(Propylene Oxide) Triblock Copolymer (EO27-PO39-EO27) in Aqueous Solution. Macromolecules 1994, 27 (21), 6046-6054. DOI: 10.1021/ma00099a017

7. Glatter, O.; Schillén, K.; Scherf, G., Formation of Micelles and Gels from Block Copolymers in Water Followed by Ultra-Sound Velocimetry and Complex Densitometry. In Trends in Colloid and Interface Science VII, Springer, Laggner, P.; Glatter, O., Eds., Progr. Polym. Sci., 1993, 93, 251-252. DOI: 10.1007/BFb0118536

6. Schillén, K.; Glatter, O.; Brown, W., Characterization of a PEO-PPO-PEO Copolymer System. In Trends in Colloid and Interface Science VII, Springer, Laggner, P.; Glatter, O., Eds., Progr. Polym. Sci., 1993, 93, 66-71. DOI: 10.1007/BFb0118476

5. Schillén, K.; Brown, W.; Konak, C., Aggregation of a Poly(Ethylene Oxide)-Poly(Propylene Oxide)-Poly(Ethylene Oxide) Triblock Copolymer in Aqueous Solution Studied Using Rayleigh-Brillouin and Dynamic Light Scattering. Macromolecules 1993, 26 (14), 3611-3614. DOI: 10.1021/ma00066a020

4. Brown, W.; Schillén, K.; Johnsen, R.; Konak, C.; Dvoranek, L., Brillouin Light Scattering from Poly(Methyl Methacrylate)/Toluene Concentrated Solutions. Macromolecules 1992, 25 (2), 802-805. DOI: 10.1021/ma00028a046

3. Brown, W.; Schillén, K.; Hvidt, S., Triblock Copolymers in Aqueous Solution Studied by Static and Dynamic Light Scattering and Oscillatory Shear Measurements. Influence of Relative Block Sizes. J. Phys. Chem. 1992, 96 (14), 6038-6044. DOI: 10.1021/j100193a072

2. Brown, W.; Schillén, K.; Almgren, M.; Hvidt, S.; Bahadur, P., Micelle and Gel Formation in a Poly(Ethylene Oxide)-Poly(Propylene Oxide)-Poly(Ethylene Oxide) Triblock Copolymer in Water Solution. Dynamic and Static Light Scattering and Oscillatory Shear Measurements. J. Phys. Chem. 1991, 95 (4), 1850-1858. DOI: 10.1021/j100157a064

1. Brown, W.; Johansson, K.; Almgren, M., Threadlike Micelles from Cetyltrimethylammonium Bromide in Aqueous Sodium Naphthalenesulfonate Solutions Studied by Static and Dynamic Light Scattering. J. Phys. Chem. 1989, 93 (15), 5888-5894. DOI: 10.1021/j100352a047

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