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Linnéa Gunnarsson: Characterization of DOPC and DOPG Vesicles in two Choline Chloride-Based Deep Eutectic Solvents

Övrigt

From: 2019-12-06 11:15 to: 12:00
Place: KC: L
Contact: peter [dot] jonsson [at] fkem1 [dot] lu [dot] se
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Bachelor Thesis presentation

 

Abstract
Deep eutectic solvents (DES) are designer solvents comprised of a quaternary ammonium salt and a hydrogen bond donor that are mixed at a 1:2 molar ratio. They are a green, biodegradable alternative to ionic liquids (ILs) that replace organic solvents in many applications. However, the high viscosity of these solvents limits their areas of use, but this can be overcome through addition of water. The characteristics of DES with additions of water has been investigated and it is believed that smaller additions can be achieved without altering the nanostructure of the DES. Vesicle formation is possible in DES, but the interactions between the lipid bilayer and the eutectic are not yet fully understood. The solvophobic effect that drives vesicle formation is likely affected by the theoretically high ionic charge of the DES. Drawing from previous research, a characterisation of vesicles in DES was attempted to contribute to the field. Vesicles made from DOPG and DOPC lipids were assembled in solutions of both 1:2 choline chloride/urea (reline) and 1:2 choline chloride/glycerol (glyceline) DES, with different additions of water. The resulting vesicles were analysed using dynamic light scattering (DLS), accompanied by a study of their bilayers using small angle X-ray scattering (SAXS). The results indicated that vesicles formed in different eutectic mixtures were of different sizes and displayed structural differences in their lipid bilayer. The type of lipid used, as well as the hydration level of the solvent were both influential factors. The differences encountered were hypothesised to result from interactions between the lipid headgroups and the DES constituents.